摘要
目的 :探讨血浆一氧化氮 (NO)和内皮素 (ET)水平在突发性聋 (突聋 )发病过程中的作用。方法 :对32例突聋患者用硝酸还原酶法测定血浆NO ,用放射免疫法测定血浆ET。结果 :突聋组血浆NO显著降低 ,ET显著升高 ,与正常对照组相比较 ,突聋组血浆NO显著降低 (P <0 .0 1) ,ET显著升高 (P <0 .0 1) ;突聋治疗前与治疗后血浆NO、ET之间差异有显著性意义 (P <0 .0 1) ;治疗有效者与无效者血清NO、ET水平的差异也有显著性意义 (P <0 .0 1)。结论 :在突聋发作过程中 ,血浆NO和ET的含量显著变化 。
Objective:To study the significance of plasm NO and ET in sudden hearing loss.Method:We studied the plasma endothelin (ET) and NO in 32 cases of sudden hearing loss with radioimmunoassay (RIA) and nitrate reductase (NR) by using RIA and NR.Result:The content of plasma ET in sudden hearing loss group is higher than that in control group ( P< 0.01), but the NO is lower (P< 0.01).The contents of plasma NO and ET between sudden hearing loss and treated sudden hearing loss group and that between the effective treatment group and effectless treatment group have significant differences (P< 0.01). Conclusion:The contents of plasma NO and ET will remarkably change during the process of sudden hearing loss and may accelerate the happening and development of the disease.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2003年第11期668-669,共2页
Journal of Clinical Otorhinolaryngology
关键词
聋
突发性
一氧化氮
内皮素
Deatness,sudden
Endothelin
Nitric oxide
