摘要
目的 深入探讨金铁锁水煎浸膏对实验关节痛的镇痛作用 ,并阐述其作用机制。方法 以福氏完全佐剂 (Fre und’scompleteadjuvant,FCA)作为实验性类风湿性关节炎 (Rheumatoidarthritis,RA)疼痛模型为基础 ,采用金铁锁水煎浸膏 (大、中、小剂量组 ) ,并设立空白对照组、模型组、中药阳性对照组和西药阳性对照组治疗 ,检测其痛阈、皮肤肿胀度和疼痛级别等的变化。结果 金铁锁水煎浸膏对实验性RA关节痛具有显著的镇痛效应 ,金铁锁水煎浸膏明显提高痛阈、减轻皮肤的肿胀度 ,降低疼痛级别等。
Objective To study the analgesic effect and mechanism of Psammosilene tunicoidesextract in treatment of experimental rheumatoid arthritis(RA).Methods Freund's complete adjuvant (FCA) was used to produce experimental RA.Different dosages of the herbal medicine (large,middle and small)were administered.And control,model,herbal medicine,and Western medicine groups were established for comparison.The pain threshold,swelling of skin,and degree of pain were examined.Results Psammosilene tunicoides has remarkable analgesic effect in experimental RA;it evidently elevates pain threshold,alleviates skin swelling and reduce pain degree.Conclusion The preparation of Psammosilene tunicoides has remarkble effect of pain reduction.
出处
《武警医学》
CAS
2003年第10期589-591,共3页
Medical Journal of the Chinese People's Armed Police Force
基金
江苏省药用植物生物技术重点实验室开放基金资助(KJS2 0 0 2 116)
