摘要
目的 研究常规机械通气 (CMV)、高频喷射通气 (HFJV)和高频双向喷射通气 (HFTJV)对重度蒸汽吸入伤犬呼吸力学和气体交换的影响。 方法 9只犬 ,重度蒸汽吸入性损伤 ,分别在上述三种条件下检测呼吸力学、循环和血气等各种参数。 结果 ( 1)三种通气方式下呼吸系统总阻力 (Rrs)、肺阻力 (RL)均显著高于对照值 (P <0 .0 1) ,呼吸总顺应性 (Crs)、肺顺应性 (CL)均显著低于对照值 ( P <0 .0 5 ) ,但三者之间比较 ,Rrs、RL、Crs、CL 的变化差异均无显著性意义。 ( 2 )CMV和HFJV均引起CO2 潴留 ,HFTJV比HFJV显著增加CO2 排出 (VCO2 ,P <0 .0 1)。 ( 3)三种通气方式的功能残气量(FRC)和PaO2 均无明显变化。 结论 三种通气方式均能克服气道阻力辅助呼吸 ,但不能使伤后高气道阻力和低肺顺应性恢复正常。CMV的通气效率类似于HFJV ,而HFTJV的通气效率则优于HFJV。
Objective To study the effects of conventional mechanical ventilation (CMV), high-frequency jet ventilation(HFJV) and high-frequency two-way jet ventilation (HFTJV) on the respiratory mechanics and gas exchange in dogs inflicted with severely by steam inhalation injury. Methods Nine mongrel dogs inflicted by steam inhalation to severe inhalation injury were served as the model. Indices of respiratory mechanics, hemodynamics and blood gas analysis were monitored respectively with the above three patterns of mechanical ventilation. Results (1)Total respiratory resistance (Rrs) and resistance of lungs (R L) were evidently higher with the ventilations than those in control(P < 0.01). And total respiratory compliance (Crs) and compliance of lungs (C L) were obviously lower with the ventilations than those in control (P < 0.05) but with no significant differences among the changes of Rrs, R L, Crs and C L. (2)Carbon dioxide (CO 2) retention could be induced by CMV and HFJV. HFTJV was much more effective than HFJV in enhancing the expiration of CO 2 (P< 0.01). (3)There was no remarkable difference in functional residual capacity (FRC) and PaO2 between dogs with three patterns of ventilation. Conclusion All these three patterns of ventilation could overcome the respiratory resistance and help respiration, but they couldn't correct the high airway resistance and low compliance of lungs already established postburn. The efficiency of CMV was similar to that by HFJV, but that of HFTJV was much better than that of HFJV.
出处
《中华烧伤杂志》
CAS
CSCD
2000年第4期234-236,共3页
Chinese Journal of Burns
基金
国家自然科学基金资助项目
