摘要
目的 了解原发性肺癌的临床特点及外科治疗效果。方法 对 1987年 4月至 2 0 0 2年 6月 180 2例肺癌住院病例进行回顾性分析 ,并对其中 132 5例手术患者进行随访 ,统计 1987年 4月至 1997年 12月间接受肿瘤切除的6 39例患者的 5年生存率。结果 肺癌患者中 ,男性 14 6 8例 ( 81 5 % ) ,女性 334例 ( 18 5 % ) ,平均年龄 ( 5 5 0 0±10 6 6 )岁。鳞癌占 5 0 7% ,腺癌占 38 5 % ,其它占 10 8%。术后总的 5年生存率为 2 9 4 % ,其中Ⅰa、Ⅰb、Ⅱa、Ⅱb、Ⅲa、Ⅲb、Ⅳ期患者的 5年生存率分别为 75 0 %、 5 1 1%、 33 3%、 2 8 0 %、 16 7% ,7 3% ,0 %。Ⅰa与Ⅰb期、Ⅱb与Ⅲa期、Ⅲa与Ⅲb期患者的 5年生存率有显著性差异。全肺切除的 5年生存率 ( 19 4 % )远远低于肺叶切除 ( 33 3% ) ,P <0 0 5。 5 0例支气管切缘癌残留患者的 5年生存率 ( 12 0 % )远远低于切缘无癌残留者 ( 30 9% ) ,P <0 0 5。结论 TNM分期、手术方式、支气管切缘是否有癌组织残留是影响术后生存率的重要因素。
Objective To elucidate the clinical characters and surgical treatment of primary lung cancer. Methods 1802 cases who hospitalized in our department from April 1987 to June 2002 were studied retrospectively and follow up surveys were carried out in 1325 who received surgical treatment. Five year survival was calculated in 639 patients who received operation from April 1987 to December 1997. Results There were 1468 (81 5 %) men and 334 (18 5 %) women in our study, with the average age of 55 00±10 66. Squamous cell carcinomas accounted for 50 7%, adenocarcinomas for 38 5 %, and others for 10 8 %. Overall 5 year survival rate was 29 4 %. Five year survival rates for stage Ⅰa, Ⅰb, Ⅱa, Ⅱb, Ⅲa, Ⅲb, Ⅳ were 75 0 %, 51 1%, 33 3%, 28 0%, 16 7%, 7 3%, 0% respectively. There were significant differences in 5 year survival rate between stage Ⅰa and Ⅰb, Ⅱb and Ⅲa, Ⅲa and Ⅲb. Five year survival rate was lower in those who received pneumonectomy (19 4%) or suffered from microscopic residual disease (12 0%) than those who received lobetomy (33 3%) or those free from microscopic residual disease (30 9%), P <0 05. Conclusion TNM stage, mode of operation and microscopic residual disease were important factors for survival rate of lung cancer.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2003年第5期516-518,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
