摘要
目的 :探讨原发性脾脏恶性淋巴瘤 (primarymalignantlymphomaofthespleen ,PLS)的病理形态学特征及诊断要点。方法 :采用常规HE染色及免疫组化染色 ,对 6例PLS进行观察。结果 :粟粒状肿块 2例 ,单发性肿块 2例 ,多发结节状肿块 2例 ,其形态特点与其组织学类型密切对应。镜下肿瘤由异型淋巴细胞构成 ,小细胞性 2例 ,大细胞性和混合细胞性 4例 ,大细胞性淋巴瘤相对多见。免疫标记显示多数病例 (5 / 6 )为B细胞源性。结论 :原发性脾脏恶性淋巴瘤组织学形态复杂多变 ,多为B细胞源性 ,结合相应的形态学特征及免疫组化结果可确诊。
Object: To explore the histopathological characteristics of splenic primary lymphoma and the criteria for its pathological diagnosis. Methods: Six cases were studied by HE-strained, immunohistochemitry, and review of the literature. Results: The gross patterns of the 6 cases includes miliary masses(2 cases), mutiple masses(2 cases), solitary masses(2 cases), which correspond closely to the various microscopic types. Large lymphocyte lymphoma(4 cases) is more often than small lymphocyte lymphoma(2 cases). In our study most of the cases(5/6) were originated from B cell.Conclusion: Histopathological changes of lymphoma primary occurred in the spleen were often variable. It's histopathological characteristics and immunophenotype are effective for the diagnosis of PLS.
出处
《中国临床医学》
2003年第5期697-698,701,共3页
Chinese Journal of Clinical Medicine
