摘要
目的 探讨联合应用善宁和生长激素治疗重症急性胰腺炎 (SAP )的疗效。方法 对 60例SAP ,随机分为善宁治疗组 (n =15 ) ,生长激素和善宁联合治疗组 (n =3 0 )以及对照组 (n =15 )。观察并对比各组治疗后血清IL 1,IL 6,TNF α和清蛋白的变化、住院天数、并发症发生率和病死率。结果 联合治疗组的中转手术率、并发症发生率、病死率、住院天数均明显低于善宁组及对照组 (均 P <0 .0 5 ) ;联合组抑制SAP的炎性细胞因子高表达及促进清蛋白合成的作用亦优于善宁组及对照组 (均P <0 .0 5 )。结论 善宁和生长激素联合应用是治疗SAP的有效方法 ;其对改善损伤器官功能及预防多器官功能障碍综合征的发生有肯定作用。
Objective To evaluate the therapeutic effect of combination of sandostatin and growth hormone (GH) in the treatment of severe acute pancreatitis (SAP ). Methods Sixty patients with SAP were divided randomly into 3 groups:(1)Sandostatin treatment(ST) group (n=15);(2)combination of sandostatin with GH treatment(CT) group (n=30) ;(3)control group (n=15). The changes in serum IL-1, IL-6,TNF-α and albumin levels after treatment, and the incidence of complications, the duration of hospital stay and cost were compared among the 3 groups. Results The complications, mortality, duration of hospital stay in the CT group were significantly shorter than those in ST group and control group (all P<0.05).The inhibiton of overexpression of inflammation mediators, correction of hypoalbuminemia in CT group was much better than those in CT group and control group(P<0.05,P<0.05).Conclusions Combined treatment with sandostatin and GH is a new effective method for treatment of SAP,it can improve the function of multiple damaged organs in SAP.
出处
《中国普通外科杂志》
CAS
CSCD
2003年第12期914-917,共4页
China Journal of General Surgery
关键词
胰腺炎
药物治疗
善宁
生长激素
细胞因子
多器官功能障碍综合征
PANCREATITIS/drug ther
ACUTE DISEASES
SANDOSTATIN/ther use
GROWTH HORMONE/ther use
DRUG THERAPY,COMBINATION
