摘要
目的 探讨烟花火药爆炸复合烧伤大鼠血浆肌酸激酶心肌同工酶 (CK MB)与心肌丙二醛 (MDA)含量的变化。方法 Wistar大鼠 12 8只 ,随机分为正常对照组 (n =8)、烧伤组 (n =4 0 )、爆炸伤组 (n =4 0 )和复合伤组 (n =4 0 ) ,分别致伤形成大鼠 2 0 %体表面积Ⅲ度烧伤、火药爆炸伤和两者复合伤。动态观察大鼠伤后 1、3、6、12、2 4h血浆CK MB ,心肌MDA含量并进行相关分析。结果 复合伤组较单因素致伤组大鼠血浆CK MB升高明显 ,心肌组织MDA含量呈类似变化 ,CK MB与MDA有相关性。结论 烟花火药爆炸复合烧伤对大鼠心肌的损害较单纯烧伤或爆炸伤更为严重 ,提示烧伤和爆炸伤有协同致伤作用 ,氧自由基代谢紊乱参与烟花火药爆炸复合烧伤后心肌的损伤。
Objective To investigate changes of CK MB in blood plasma and MDA contents in cardiac muscle of rats with complex burn caused by burn and gunpowder explosion. Methods 128 Wistar rats were randomly divided into 4 groups: normal control group ( n =8), simple burn group ( n =40), explosive injury group ( n =40) , combined explosion and burn group ( n =40). The rats were injured to 20% BSA third degree burn, gunpowder explosive injury and complex injury with burn and explosion respectively. Dynamic observations were done at 1,3,6,12 and 24 h post injury on the changes of CK MB in blood plasma and MDA contents in cardiac muscle. Results Compared with simple burn group and explosion injury group, the complex burn group’s CK MB activities of the blood plasma and MDA contents in cardiac muscle were elevated significantly,and the changes of CK MB activity were correlated to that of MDA. Conclusion The rat’S myocardial injury is more obvious after complex burn and explosion than that of simple burn or simple explosion. The activation of MDA participates in the injury of cardiac muscle with complex burn caused by burn and gunpowder explosion.
出处
《安徽医科大学学报》
CAS
2003年第6期434-436,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省卫生厅重点学科资金资助
