摘要
目的 :探讨治疗糖尿病肾病 (DN)慢性肾衰竭的较理想治疗方法。方法 :将 2 9例糖尿病慢性肾衰竭患者按中医辨证分为脾肾气阳虚型、脾肾气阴虚型、肝肾阴虚型和阴阳两虚型 ,分别给予香砂六君子汤加减等补气健脾益肾 ,参芪地黄汤益气滋肾 ,杞菊地黄汤加减养阴平肝 ,金匮肾气丸和地黄饮子阴阳两补 ;同时与 2 3例西药常规治疗对照组进行比较 ,观察两组患者治疗前后临床症状、空腹血糖、2 4 h尿蛋白定量、血肌酐、尿素氮、总胆固醇和甘油三酯。结果 :治疗组总有效率为 89.5 % ,对照组总有效率为 6 5 .0 % ,两组总有效率比较差异有显著性 (P<0 .0 5 )。中医辨证治疗组治疗后空腹血糖、2 4 h尿蛋白、血肌酐和尿素氮均明显降低 (P<0 .0 5或P<0 .0 1) ,总胆固醇和甘油三酯也有改善 ,但差异无显著性 (P>0 .0 5 )。西医常规治疗组治疗后仅对空腹血糖有明显降低作用 (P<0 .0 1) ,对其他指标有改善作用但不明显。结论 :中西医结合治疗糖尿病肾病合并慢性肾衰竭较单纯西医治疗效果为好。
Objective: To explore the better treatment in the chronic renal failure (CRF) patients due to diabetic nephropathy (DN). Methods: Twentynine CRF patients due to DN were divided into four groups according to their traditional Chinese medicine differentiations: deficiency of spleenYangQi and kidneyYangQi (脾肾气阳虚), deficiency of spleenYinQi and kidneyYinQi(脾肾气阴虚), deficiency of liverYin and kidneyYin(肝肾阴虚), deficiency of both Yin and Yang(阴阳两虚). They were treated by modifide decoction of six noble drugs(香砂六君子汤) adding aucklandia root and amomum fruit to warming the kidney and strengthen the spleen, modified decoction of six drugs including rehmannia and adding Danshen and astragalus root(参芪地黄汤) to supplementing Qi nourishing kidney(益气滋肾), modified decoction of six drugs including rehmannia and adding wolfberry and chrysanthemum(杞菊地黄汤) to nourshing Yin and calming the liver(养阴平肝), bolus for tonifying the kidneyQi(金匮肾气丸) and Dihuang Yinzi(地黄饮子) to nourshing Yin and Yang(阴阳两补). The cure groups were compared with the contrast groups(23 cases) in clinic syndromes, fasting blood sugar, 24 hours urinary protein excretion, serum creatinine(SCr), blood urea nitrogen(BUN), total cholesterol(TC), triglyceride(TG) before and after treatment. Results: The total effective rate in the cure group was 89.5 percent and in the control group was 65.0 percent, while the difference was significant(P<0.05). In the cure group, the fasting blood sugar, 24 hours urinary protein, BUN, SCr were all decreased after treatment (P<0.05 or P<0.01), the improvement of TC and TG were observed but the difference was not significant (both P>0.05). [HJ5”:4/9]The routine western medicine could decrease the fasting blood sugar (P<0.01), but the effect of improving the others indexes was not significant. Conclusion: Integrated traditional Chinese and western medicine treatment shows better effect than the single western medicine in CRF patients due to DN.
出处
《中国中西医结合急救杂志》
CAS
2003年第6期369-371,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
中西医结合
糖尿病肾病
慢性肾衰竭
疗效观察
辨证分型
中药方剂
diabetic nephropathy
chronic renal failure
integrated traditional Chinese and western medicine therapy
