摘要
目的 :探讨纤维蛋白原 (Fg)在冠状动脉疾病不同阶段的变化 ,以及在急性冠状动脉综合征 (ACS)中与心肌肌钙蛋白Ⅰ (cTnⅠ )的关系。方法 :对 5 2例ACS病人、49例稳定型心绞痛 (SA)病人和 5 0例年龄、性别匹配的正常人 (NS)进行Fg和cTnⅠ测定 ,分析二者的相关关系。结果 :SA组病人Fg测定值为( 3 .2 9± 0 .68)g/L ,低于ACS组病人 ( 3 .89± 1.0 8) g/L ,两者比较有统计学意义 (P <0 .0 0 1) ,NS组Fg测定值最低 ,为 ( 2 .91± 0 .63 ) g/L ,与ACS组及SA组比较有统计学意义 (P <0 .0 0 1或P <0 .0 1)。ACS病人Fg和cTnⅠ呈明显正相关关系 (P =0 .0 0 4)。结论 :Fg在冠状动脉疾病及血栓形成中起重要作用 ,ACS病人炎症与心肌损伤共存且相关。
Objective: To explore whether plasma fibrinogen (Fg)there is a stratification among patients with different stages of coronary artery disease, and to assess the relationship of plasma fibrinogen (Fg) and serum cardiac troponin Ⅰ (cTnⅠ) in patients with acute coronary syndrome (ACS). Methods: 52 patients with ACS(ACS group), 49 patients with stable angina(SA group), and 50 age and sex-matched normal subject(NS group) were studied. Plasma Fg and serum cTnⅠ were tested and compared. Results: Plasma Fg (g/L) was significantly lower in patients presenting with SA than with ACS (3.29±0.68 vs 3.89±1.08, P <0.001), The NS group showed the lowest levels (2.91±0.63) g/L(vs ACS, P <0.001; vs SA, P <0.01). Significant correlation had been found between Fg and cTnⅠ levels in ACS patients(P=0.004). Conclusion: Fg take an important role in coronary heart disease and atherothrombosis. In patients with acute coronary syndrome.(ACS) increased inflammation and cardiac injury seem to coexist and correlate.
出处
《中西医结合心脑血管病杂志》
2003年第12期688-689,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
