摘要
目的观察芪苈强心胶囊对慢性肾衰竭合并慢性心力衰竭患者心功能的影响。方法符合诊断标准的患者100例按照随机数字表法分为对照组和研究组各50例。2组患者均常规应用利尿、强心等药物及血液透析治疗,研究组在常规治疗基础上加服芪苈强心胶囊。观察治疗前及治疗8周后2组患者血浆脑钠肽(BNP)、醛固酮(ALD)表达水平、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、6 min步行距离及肾功能的变化。结果治疗前2组患者血浆BNP、ALD表达水平及LVEDD、LVEF、6 min步行距离、血肌酐、尿素氮、血钾比较差异均无统计学意义(P>0.05)。与治疗前比较,2组患者治疗8周后血浆BNP、ALD表达水平、血肌酐、尿素氮、血钾均下降(P<0.05),LVEDD、LVEF及6 min步行距离均改善(P<0.05),且研究组比对照组均改善显著(P<0.05)。结论芪苈强心胶囊辅治能明显降低慢性肾衰竭合并慢性心力衰竭患者血浆BNP、ALD及血肌酐、尿素氮、血钾水平,显著改善心肾功能,提高患者生活质量。
Objective To observe the influence of Qiliqiangxin capsule in treating patients with chronic renal failure complicated by chronic heart failure.Methods One hundred patients met the diagnosis criteria were randomly divided into control group and research group using digital table,50 cases in each group.Both groups were used regular treatment including diuretics,cardiotonic drugs and blood dialysis,on basis of routine treatment,research group were added Qiliqiangxin capsule.Before treatment and 8 weeks after treatment,changes of plasma natriuretic peptide(BNP),aldosterone(ALD),left ventricular end-dilation diameter(LVEDD),left ventricular ejection fraction(LVEF),6 min walk distance,and renal function were observed and compared.Results Before treatment,there were no significant difference between the two groups in plasma BNP,ALD,LVEDD,LVEF,6 min walk distance,SCR,BUN and K^+(P >0.05).compared with before treatment,the levels of plasma BNP,ALD,SCr and K^+ were decreased(P <0.05),LVEDD,LVEF and 6 min walk distance were improved(P <0.05),the improvement in research group were more obvious than those of control group(P < 0.05).Conclusion Qiliqiangxin capsule can obviously decrease plasma BNP,ALD,SCr,BUN and K^+ in patients with chronic renal failure and chronic heart failure,improve heart and renal function,improve the life quality of the paitens.
出处
《疑难病杂志》
CAS
2015年第3期288-290,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
肾衰竭
慢性
心力衰竭
慢性
芪苈强心胶囊
肾功能
Renal failure,chronic
Heart failure,chronic
Qiliqiangxin capsule
Renal fucntion
