摘要
目的 探讨超分割放疗治疗非小细胞肺癌 (NSCLC)的疗效。方法 1995年 10月至 2 0 0 0年 1月我科收治经病理证实的原发性Ⅰ～Ⅲ期NSCLC 5 0例。非随机性分组 ,超分割放疗 2 5例为治疗组 ,给予肿瘤量 68.9～ 74.6Gy/ 6～ 6.5周 ,平均肿瘤量 70 .3Gy/ 6～ 6.5周 ;常规放疗 2 5例为对照组 ,给予肿瘤量 64 .2～ 70 .4Gy/ 6～ 7周 ,平均肿瘤量 68.6Gy/ 6～ 7周。患者入组前未进行过化疗或免疫治疗。 结果 放疗结束时 ,超分割放疗组肿瘤消退率为 80 % ( 2 0 / 2 5 ) ,常规放疗组为 48% ( 12 / 2 5 ) ( χ2 =5 .5 6,P <0 .0 5 )。超分割放疗组 1、2、3年生存率分别为 68% ( 17/ 2 5 )、60 % ( 15 / 2 5 )和 3 6% ( 9/ 2 5 ) ;常规放疗组为 5 2 % ( 13 / 2 5 )、3 2 % ( 8/2 5 )和 2 0 % ( 5 / 2 5 )。两组 2年生存率比较 ,χ2 =3 .95 ,P <0 .0 5 ;两组 3年生存率比较 ,χ2 =1.5 8,P >0 .0 5。超分割放疗组 1、2、3年局控率分别为 72 % ( 18/ 2 5 )、60 % ( 15 / 2 5 )和 44 % ( 11/ 2 5 ) ;常规放疗组分别为 64 %( 16/ 2 5 )、48% ( 12 / 2 5 )和 3 2 % ( 8/ 2 5 )。两组 3年局控率比较 ,χ2 =0 .76,P >0 .0 5。结论 根据直接法统计 ,超分割放疗治疗NSCLC疗效优于常规放疗 ,但其长期生存尚需要进一步研究。
Objective To investigate the efficacy of hyperfractionated radiotherapy (HRT) for non small cell lung cancer (NSCLC). Methods Fifty patients with stageⅠ Ⅲ NSCLC were treated in our department from Oct. 1995 to Jan. 2000. All patients had the pathological diagnosis. The patients were divided into two groups according to their entrance sequence: 25 patients were treated by HRT as the treatment group given the tumor doses (DT) 68.9 74.6 Gy/6 6.5 weeks, mean DT 70.3 Gy/6 6.5 weeks; 25 patients were irradiated by conventional fractionation (CF) as the control group given DT 64.2 70.4 Gy/6 7 weeks, mean DT 68.6 Gy/6 7 weeks. No patients received chemotherapy or immunotherapy before this treatment. Results The effective rate after the radiotherapy was 80% (20/25) in the HRT group and 48% (12/25) in the CF group (χ 2=5.56,P< 0.05 ). The 1 , 2 , 3 year survival rate of the HRT group was 68% (17/25), 60% (15/25) and 36% (9/25) respectively. The 1 , 2 , 3 year survival rate of the CF group was 52% (13/25), 32% (8/25) and 20% (5/25) respectively. The 2 year survival rate was significantly different between two groups (χ 2=3.95,P< 0.05 ). The 1 , 2 , 3 year local progression free rate of the HRT group was 72% (18/25), 60% (15/25) and 44% (11/25) respectively. The 1 , 2 , 3 year local progression free rate of the CF group was 64% (16/25), 48% (12/25) and 32% (8/25) respectively. Conclusion According to the direct calculation, the efficacy of HRT for NSCLC is higher than that of CF. It is necessary to follow up the long term survival for the patients treated with HRT.
出处
《中国肺癌杂志》
CAS
2003年第3期211-212,共2页
Chinese Journal of Lung Cancer
关键词
放疗
治疗
NSCLC
非小细胞肺癌
肿瘤
Prospective Hyperfractionated radiotherapy Non small cell lung cancer Efficacy
