摘要
目的观察中药清瘟败毒饮与中药针剂痰热清注射液治疗甲型H1N1流感病毒性肺炎的疗效。方法选择2016年1月至2018年3月甘肃省酒泉市人民医院和酒泉市肃州区疾控中心收治的90例甲型H1N1流感病毒性肺炎患者,按随机数字表法分为治疗组与对照组,治疗组50例在常规西药基础上用中药清瘟败毒饮加味与中药针剂痰热清注射液治疗,对照组40例在常规西药基础上选用氨溴索,奥司他韦150 mg西药治疗,分别观察用药前后临床症状及血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-8、IL-10及C反应蛋白(CRP)水平。结果治疗组总有效率为96. 0%,对照组总有效率为70. 0%,治疗组总有效率显著高于对照组(χ2=11. 436,P=0. 001)。治疗后,两组血清TNF-α、IL-6、IL-8、CRP水平均低于治疗前,IL-10水平高于治疗前,且治疗组血清TNF-α、IL-6、IL-8、CRP水平均低于对照组,IL-10水平高于对照组(P <0. 01)。结论中药清瘟败毒饮与中药针剂痰热清联用可减轻机体炎症反应,使患者症状改善,在甲型H1N1流感病毒性肺炎防治工作中具有重要意义。
Objective To observe the efficacy of Qingwen Baidu Decoction combined with Tanreqing Injection in the treatment of viral pneumonia caused by influenza A virus subtype H1 N1. Methods A total of 90 patients with viral pneumonia caused by influenza A virus subtype H1 N1 who received treatment at Centers for Disease Control of Suzhou District from January 2016 to March 2018 were selected and divided into treatment group and control group randomly. The50 patients in treatment group was treated with routine Western medicine and Qingwen Baidu Decoction combined with Tanreqing Injection,and the 40 patients in control group was treated with routine Western medicine and oseltamivir( 150 mg,P. O.,bid). The clinical symptoms and the level of tumor necrosis factor( TNF)-α,interleukin( IL)-6,IL-8,IL-10 and C-reactive protein( CRP) were observed before and after the treatment. Results The total efficacy in treatment group was significantly higher than that in control group( 96. 0% vs 70. 0%,χ2= 11. 436,P = 0. 001). After the treatment,the level of TNF-α,IL-6,IL-8 and CRP were lower in both group,the level of IL-10 was higher in both group,and the level of TNF-α,IL-6,IL-8,CRP were lower in treatment group than those in control group,the level of IL-10 was higher in treatment group than that in control group( all P < 0. 01). Conclusion The combination of Qingwen Baidu Decoction and Tanreqing Injection can alleviate the inflammatory reaction and improve the symptoms of patients,which is of great significance in the prevention and treatment of viral pneumonia caused by influenza A virus subtype H1 N1.
作者
田有忠
王东雁
刘守亮
吴河山
陈敬德
高峰
刘杰
李辉
陶雪梅
TIAN You-zhong;WANG Dong-yan;LIU Shou-liang;WU He-shan;CHEN Jin-de;GAO Feng;LIU Jie;LI Hui;TAO Xue-mei(Centers for Disease Control of Suzhou District,Jiuquan,Gansu 735000,China)
出处
《中国临床研究》
CAS
2019年第2期260-263,共4页
Chinese Journal of Clinical Research
关键词
甲型H1N1流感
病毒性肺炎
清瘟败毒饮
痰热清注射液
Influenza A virus subtype H1N1
Viral pneumonia
Qingwen Baidu Decoction
Tanreqing Injection
