摘要
目的使用近红外光学成像技术研究增龄对额极皮层在工作记忆中激活的影响。方法青年组女性健康被试8人、中年组女性健康被试7人参加本研究,两组被试进行斯腾伯格项目再认任务,使用近红外光学成像技术监测任务期间双侧额极区的血流动力学变化,计算额极区氧合血红蛋白的偏侧指数并进行统计学分析。结果青年组和中年组相比斯腾伯格任务的低记忆负荷和高记忆负荷任务的正确率无统计学差异(P>0.05)。在低记忆负荷任务中两组的反应时间无统计学差异;而在高记忆负荷任务中,中年被试的反应时间显著长于青年组(P<0.05)。青年组额极激活表现为右侧优势,而中年组表现为双侧激活反应(P<0.05)。结论本研究结果支持额极功能随着老化过程发生改变,而且随老化出现的前额叶(PFC)偏侧性减弱的HAROLD模型早在中年阶段就可表现出来。
Objective To employ near-infrared spectroscopy(NIRS) to measure frontal pole activity while younger and older sub-jects performed a working memory( WM〗) task.Mte hods 8 healthy younger and 7 healthy older women subjects were recruited.All subjects were performed a Sternberg′s itemr-ecognition task in which the memory -set size varied between 1 and 6 digits.NIRS was used to measure frontal pole activity, laterality index were calculated.Results During Sternberg′s task, the accuracy of low and high memory-load between younger and older groups had no differences.However, in high memory-load tasks, older subjects performed slower than younger subjects ( P<00.5 ) .Younger subjects showed right lateral responses with a stronger right than left activation in the frontal pole, whereas older sub-jects showed bilateral-responses( P<00.5 ) .Conclusions The laterality in frontal pole activity changes with aging, which is consistent with the HAROLD model.Working memory task causes asymmetrical frontal pole activation in younger adults, while older adults tends to the re-duced hemispheric lateralization, which suggest HAROLD pattern develops before old age.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2014年第20期5637-5639,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金(81171143)
清华-裕元医学科学研究基金
关键词
近红外光学成像技术
额极
工作记忆
老化
Near-infrared spectroscopy
Frontal pole
Working memory
Aging
