摘要
目的 观察PT方案初治小细胞肺癌的疗效和毒性。方法 拓扑替康 1 2mg/(m2 ·d) ,d1～ 5,顺铂 2 5mg/(m2 ·d) ,d1～ 3 。 3周为 1周期。结果 有效率 (RR) 66 7% ,其中CR 6 7% ,PR 60 0 % ;毒副作用主要是骨髓抑制 ,Ⅲ～Ⅳ度白细胞下降率 3 7 0 % ,Ⅲ～Ⅳ度消化道反应仅 6 7%。结论 PT方案作为初治小细胞肺癌有效率高 ,主要毒性是白细胞下降。
Objective The aim of this study was to investigate the efficacy and toxicity of topotecan+cisplatin(first line)in the treatment of the patients with small cell lung cancer(SCLC).Methods The dose of topotecan was 1.2mg/(m 2·d) for 5 days and cisplatin was 25 mg/(m 2·d) for 3 days,to repeat every 3 weeks.Results The response rate was 66.7%(complete response 6.7% and partial response 60%).Bone marrow suppression was the main toxicity.Grade Ⅲ～Ⅳ neutropenia was observed in 37.0%,Grade Ⅲ～Ⅳ nausea and vomiting was only 6.7%.Conclusions more efficacy when TP regimen used as the first line of patients with SCLC,The main toxicity is neutropentia.
出处
《河南肿瘤学杂志》
2004年第1期25-26,共2页
Henan Journal of Oncology
