摘要
目的:观察超短波疗法对慢性阻塞性肺疾病(chronicobstructivepul-monarydisease,COPD)患者气道炎症的影响,探讨超短波治疗慢性阻塞性肺疾病的作用机制。方法:随机选取74例急性发作期COPD患者,根据治疗方法不同随机分为超短波治疗组(常规治疗+超短波治疗)42例,对照组(常规治疗)32例。两组病程、病情及常规治疗同质,治疗前后分别检测2组患者血液中白介素8(interleukin-8,IL-8)、肿瘤坏死因子(tumornecrosisfac-tor-α,TNF-α)、粒细胞集落刺激因子(granulocyte,G-CSF)。结果:对照组治疗前后IL-8犤(236.10±52.60)ng/L和(197.90±62.80)ng/L犦,G-CSF犤(120.75±21.32)ng/L和(109.92±22.96)ng/L犦差异有显著性意义(t=1.93,1.95;P均<0.05);TNF-α犤(38.01±7.10)pmol/L和(36.85±4.08)pmol/L犦差异无显著性意义(t=1.47;P>0.05)。超短波治疗组患者治疗前后IL-8犤(232.36±76.34)ng/L和(108.48±40.50)ng/L犦,TNF-α犤(39.96±6.01)pmol/L和(27.50±3.88)pmol/L犦,G-CSF犤(125.40±21.93)ng/L和(96.52±19.01)ng/L犦,差异均有显著性意义(t=1.92,1.97,1.89;P均<0.05);与对照组比较上述3项指标差异亦有显著性意义(t=1.98,1.87,1.89;P<0.05)。结论:超短波通过降低气道炎症,改善COPD患者的肺功能。
AIM:To observe the effect of ultrashort wave therapy on the airway inflammation in patients with chronic obstructive pulmonary disease( COPD) ,and to explore the mechanism of ultrashort wave therapy in the treatment of COPD. METHODS:Seventy four patients with COPD of acute episode were randomly divided into 2 groups according to different treatment:ultrashort wave group(regular treatment+ ultrashort wave therapy,n=42) and control group(regular treatment,n=32).The courses,patients'condition and regular treatment were the same in the two groups.The level of interleukin 8(IL 8), tumor necrosis factor α (TNF α )and granulocyte colony stimulating factor(G CSF) in serum of the two groups were tested before and after treatment respectively. RESULTS:There were significant differences in the levels of IL 8[(236.10± 52.60) ng/L and(197.90± 62.80) ng/L]and G CSF[(120.75± 21.32) ng/L and(109.92± 22.96) ng/L]before and after treatment in the control group(t=1.93,1.95;P < 0.05),while the difference in TNF α [(38.01± 7.10) pmol/L and(36.85± 4.08) pmol/L]was not significant(t=1.47;P >0.05).There were significant differences in the levels of IL 8[(232.36± 76.34) ng/L and(108.48± 40.50) ng/L], TNF α [(39.96± 6.01) pmol/L and(27.50± 3.88) pmol/L]and G CSF[(125.40± 21.93) ng/L and(96.52± 19.01) ng/L]before and after treatment in the ultrashort wave group(t=1.92,1.97,1.89;P < 0.05),and were significantly different from those in the control group(t=1.98,1.87,1.89;P< 0.05). CONCLUSION:Ultrashort wave therapy can improve the pulmonary function by reducing the airway inflammation in patients with COPD,is safe and effective to the COPD of acute episode.
出处
《中国临床康复》
CSCD
2004年第6期1066-1067,共2页
Chinese Journal of Clinical Rehabilitation
