摘要
目的 评价Ⅲ期非小细胞肺癌序贯疗法与同时疗法的疗效。方法 6 0例Ⅲ期非小细胞肺癌患者随机分为 2个组。序贯组 30例 ,NVB 2 5mg /m2 d1·8DDP 2 0mgd1～ 5 ,每 3周为 1周期 ,共 2个周期 ,第 2周期后 2 1天开始放疗。射野包括肺部原发灶和纵隔淋巴结引流区 ,常规分割放射治疗 8Mv XrayDT6 0Gy / 30f/ 6w。同时组 30例 ,NP方案开始第 1天开始放疗 ,化疗 ,放疗方案同序贯组。结果 近期疗效 (CR +PR)序贯组 5 6 .6 7% ,同时组 83.33% (χ2 =5 .0 7,P =0 .0 2 4 ) ,序贯组与同时组的平均生存期 ,中位生存期及 1、2、3年生存率分别为 :19.6 4月 ,2 3月 ,5 9.6 3% ,31.94 % ,6 .39%及 2 6月 ,35月 ,74 .0 3% ,5 6 .6 1% ,2 1.2 3% (χ2 =4 .34,P =0 .0 371)。两组病例近期疗效及平均生存期 ,中位生存期 ,1、2、3年生存率差异均具有显著意义。毒副作用主要是骨髓抑制和消化道反应 ,但均可耐受 ,无明显差异。结论 同时组治疗Ⅲ期NSCLC疗效明显优于序贯组 ,近期疗效及生存率有明显提高。
ObjectiveTo evaluate the effects of sequential therapy and concurrent therapy for stage Ⅲ non-small cell lung cancer(NSCLC). Methods60 patients with stage Ⅲ NSCLC were randomized into two groups. Sequential group: 30 patients received NVB 25mg /m 2 d1·8, DDP 20mg d1-d5,1 /3w×2. On the twenty-first day after the second circle radiotherapy was given. The treatment fields covered clinical tumor and lymph nod involved with a dose of 8Mv-X ray D_T 60Gy /30f /6w.Concurrent group: 30 patients received 'NP' concomitant radiotherapy as well. ResultsThe overall response (CR+PR) rate was 56.67% in sequential group and was 83.33% in concurrent group (χ 2=5.07,P=0.024). The mean, median survival periods were 19.64 months and 23 months, and the 1-,2-and 3-year survival rates were 59.63%, 31.94%, 6.39%,for sequential group. 26 months and 35 months 74.03%, 56.61%, 21.23% for concurrent group, respectively (χ 2=4.34,P=0.0371).The differences of overall response rate, The mean and median survival periods and the 1-,2- and 3-year survival rates between the two groups was statistically significant. The major toxic effects were myelosuppression and gastrointestinal tract reactions and were tolerable in both groups. ConclusionsThe effect between the two groups was statistically significant.
出处
《肿瘤》
CAS
CSCD
北大核心
2003年第3期238-240,共3页
Tumor
