摘要
目的 对比乳腺癌术后以THP为主及ADM为主的两种化疗方案的疗效及毒副反应。方法 72例Ⅱ、Ⅲ期乳腺癌术后患者中42例用CTF方案(CTX+THF+5-Fu)化疗6个疗程,30例用CAF方案(CTX+ADM+5-Fu)化疗6个疗程,观察这两种方案的毒副反应及疗效。结果 THP组白细胞减少发生率为47.6％,心电图异常发生率4.8％,脱发发生率33.3％,胃肠反应发生率33.3％:ADM组白细胞减少发生率为76.7％,心电图异常发生率20.0％,脱发发生率100.0％,胃肠反应发生率56.7％。结论 CTF方案是乳腺癌术后理想的化疗方案,其疗效与CAF方案相当,但其毒副反应较轻,特别是白细胞减少、心脏毒性及脱发作用较小。毒副反应轻可减少患者对化疗的恐惧情绪,提高患者的生活质量。
Objective To evaluate the efficacy and toxicity of THP-containing regimen or ADM-containing regimen in the treatment of breast cancer after operation. Method Seventy-two cases were stageⅡ -Ⅲ breast cancer after operation. Forth-two cases were treated by THP-containing regimen for 6 cycles,and 30 cases were treated by ADM-containing regimen for 6 cycles.Results THP-containing regimen:The rate of leukopenia was 47.6% , cardiac toxicity 4.8% .alopecia 33.3% ,nausea and vomiting 33.3% .ADM-containing regimem: The rate of leukopenia was 76.7% ,cardiac toxicity 20.0% , alopecia 100.0% , nausea and vomiting 56.7% . Conclusion Compared with ADM-containing regimen, THP-containing regimen is an effective and lower toxicity chemotherapy for breast cancer after operation, specially lower cardiac toxicity leakopenia and alopecia. The lower toxicity can diminish patient afraid of chemotherapy. It is benefit for the quality of life(QOL) of patient.
出处
《中国肿瘤临床与康复》
2004年第1期45-46,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
