摘要
采用肺巨噬细胞存活率、吞噬率和细胞内ATP水平等观察指标,比较研究了矽肺宁、锌和矽肺宁—锌的抗粉尘细胞毒作用。结果表明,三种药物均能保护AM拮抗粉尘细胞毒性,矽肺宁—锌最为有效,提示矽肺宁与锌可能存在联合作用,为矽肺宁—锌用于尘肺临床提供了实验依据。
The anti-cytotoxic capacity of Xifeining,zinc and Xifeining-zinc during dust damage were studied comparatively by a series of alveoli macrophage(AM) indices, including its viability, percentage of phagocytosis, and its ATP levels. The results showed that all these preparations could protect AM from cytotoxicity of dust. Among them Xifeining-zinc appeared to be more effective. It suggested that it would be possible to have sort of combinative effect between Xifeining and zinc, providing an experimental evidence for application of Xifeining-zinc in the pneumoconiosis clinic.
出处
《职业医学》
1992年第6期322-324,共3页
China Occupational Medicine
关键词
矽肺宁
锌
尘肺
粉尘
毒性
药物
Xifeining-zinc,antagonizing dust-cytotoxicity,cell culture
