摘要
目的 :探讨急性白血病 (AL)患者NOS表达与Pgp/mdr 1的关系。方法 :采用免疫组织化学法检测i NOS ,eNOS ,Pgp表达 ;RT PCR检测iNOS基因 ,mdr 1基因表达。结果 :AL患者NOS表达较对照升高 ,iNOS与Pgp/mdr 1基因表达之间呈高度正相关 (r=0 .6 80 ,P <0 .0 1)。结论
Objective To determine the relationship between nitric oxide synthase (NOS) expression and Pgp/mdr-1. Methods The expressions of iNOS, eNOS, and Pgp were detected by immunohistochemistry, and the expressions of iNOS gene and mdr-1 gene were detected by RT-PCR.Results NOS expression increased in patients with acute leukemia compared with that of the controls. There was some correlation between iNOS and Pgp/mdr-1 gene expression. Conclusion NO may influcence multiple drug resistance in patients with acute leukemia.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第1期25-27,共3页
Journal of Central South University ：Medical Science
基金
卫生部资助课题 (0 60 73 0 1 4)
