摘要
目的 了解传染性非典型肺炎 (世界卫生组织又称严重急性呼吸综合征 ,SARS)患者外周血T淋巴细胞亚群的变化。方法 采用流式细胞仪对 93例临床确诊的SARS患者、5 0例获得性免疫缺陷综合征 (AIDS)患者及 6 4例健康体检者外周血T淋巴细胞亚群进行检测。 93例患者中 ,男4 0例、女 5 3例 ;年龄 17～ 88岁 ,平均 4 4岁 ;重型 35例、普通型 5 8例。结果 健康体检者外周血CD+ 3 、CD+ 4 、CD+ 8分别为 (15 2 7± 4 70 )、(787± 2 5 7)、(6 33± 2 80 )个 / μl;93例急性期SARS患者分别为(72 2± 5 33)、(438± 35 3)、(30 7± 2 17)个 / μl,均有不同程度的下降 (P值均 <0 .0 1) ,重症病例下降尤其明显 ,5例死亡患者外周血CD+ 4 均低于 2 0 0个 / μl;SARS患者恢复期CD+ 3 、CD+ 4 、CD+ 8多数恢复正常。而AIDS患者以CD+ 4 降低为主 ,为 (2 96± 2 98)个 / μl;且CD+ 8升高 ,为 (818± 5 6 6 )个 / μl。 结论SARS患者有明显的细胞免疫损伤。
Objective To investigate the changes of subsets of blood T lymphocyte in patients with severe acute respiratory syndrome (SARS) and their clinical significance.Methods Subsets of blood T lymphocyte in 93 patients with SARS were detected by flow cytometer. The patients comprised 40 men and 53 women, aged 17-88 years (average 44 years). The results detected in 64 normal subjects and 50 patients with AIDS served as controls.Results The numbers of CD + 3, CD + 4, and CD + 8 lymphocytes all significantly decreased in acute phase of SARS patients compared with those in normal persons. Their findings was different from what we observed in patients with AIDS who had decreased CD + 4, but increased CD + 8 counts. The counts of CD + 3, CD + 4, and CD + 8 lymphocytes decreased more apparently in patients with critical SARS. All the five patients who died had CD + 4 counts less than 200/μl. As the patients′ conditions improved, the counts of CD + 3, CD + 4, and CD + 8 gradually returned to normal.Conclusion The patients with SARS were found having damage of cellular immunity markedly.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2003年第6期343-346,共4页
Chinese Journal of Tuberculosis and Respiratory Diseases
关键词
传染性非典型肺炎
外周血
T淋巴细胞亚群
流式细胞仪
Severe acute respiratory syndrome (SARS)
Pneumonia
T-lymphocyte subsets
Immunity, cellular
