摘要
目的 :本文研究鹅去氧胆酸 (CDCA)对呼吸系统的影响。方法 :分别采用浓氨水诱咳法、二氧化硫诱咳法、气管容积法、气管螺旋条法和酚红排泌法。结果 :高、低剂量的CDCA均能极显著地抑制浓氨水及二氧化硫所致小鼠咳嗽潜伏期和咳嗽次数 ;CDCA能显著地抑制磷酸组胺所致的豚鼠在体及离体气管平滑肌收缩 ;CDCA还能极显著地增加小鼠呼吸道的酚红排泌量。结论 :CDCA具有镇咳、平喘及祛痰作用。
Objective:In this paper,antitussive,antiasthmatic and expectorant action of chenodeoxycholine acid (CDCA) were studied.Method:The method of strong aqua ammoniae induced cough and sulfur dioxide induced cough,the method of tracheal volume and tracheal spiral line,and phenolsulfonphthalein excretion test.Results: CDCA was able to prolong cough latent period and decrease cough rate significantly in mice resulted from strong aqua ammoniae and sulfur doxide,and inhibit contraction of whole-body or extracorpored tracheal smooth muscle in guinea pig resulted from histamine phosphate.Besides, CDCA can increase phenolsulfonphthalein excretion quantity of trachea in mice,singnificantly.Conclusion:CDCA has antitussive,antiasthmatic,expectorant actions.
出处
《中药材》
CAS
CSCD
北大核心
2004年第3期206-208,共3页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金 (93 660 0 84)资助
关键词
鹅去氧胆酸
镇咳
平喘
祛痰
中药
Chenodeoxycholine acid
Antitussive action
Antiasthmatic action
Expectorant action
