摘要
目的 探讨洛伐他汀和氟伐他汀对急性冠脉综合征患者血清高敏C 反应蛋白 (hs CRP)及血脂水平的影响。方法 78例急性冠脉综合征患者随机单盲分为 3组 ,其中对照组 (A组 ) 18例 ;洛伐他汀组(B组 ) 30例 ,2 0mg/d ;氟伐他汀组 (C组 ) 30例 ,2 0mg/d ;随访 30天 ,检测患者治疗前后 30天血清的hs CRP浓度和血脂浓度变化。结果 治疗 30天后 ,B、C组能显著降低血总胆固醇 (TC)、甘油三酯 (TG)及低密度脂蛋白 (LDL)水平、升高血高密度脂蛋白 (HDL) ;两组间疗效无明显差异。B、C组能显著降低hs CRP的浓度 ,两组间疗效无明显差异。B、C组患者的血清hs CRP水平降低与血清TC、TG、LDL的水平降低、HDL的水平升高不相关。结论 洛伐他汀和氟伐他汀治疗急性冠脉综合征患者 30天就可明显改善血脂 ,降低hs CRP水平 。
Objective To explore the effect of lovastatin and fluvastatin on the serum levels of high sensitivity C reactive protein(hs CRP) and blood lipid in the patients with acute coronary syndrome(ACS) after 30 day treatment.Methods 78 ACS patients were randomly divided into three groups: group A(n=18) as control,group B(n=30)treated with lovastatin,20mg per day,group C(n=30) with fluvastatin,20mg daily.The levels of blood lipid and hs CRP were measured before and 30 days after the treatment.Results After 30 day treatment,the levels of total cholesterol(TC),triglyceride(TG),and low density lipoprotein(LDL) significantly decreased in group B and group C,and high density lipoprotein(HDL)significantly increased in both groups.There was no significant difference between group B and group C.The serum level of hs CRP significantly decreased in group B and group C,with no significant difference in effect between group B and group C.The decrease of hs CRP levels in group B and C was not related to the decrease of TC,TG and LDL levels and the increase of HDL level.Conclusion 30 day treatment with lovastatin and fluvastatin can improve the blood lipid levels and decrease the serum hs CRP levels in patients with acute coronary syndrome,both of which have a beneficial effect of antiinflammation and stabilizing plaque.
出处
《中国综合临床》
北大核心
2004年第5期403-405,共3页
Clinical Medicine of China
