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肾功能不同损害期患者血清胱抑素C与血肌酐、肌酐清除率的相关性研究 被引量:46

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摘要 目的 :探讨肾功能不同损害期的肾病患者血清胱抑素C (CystatinC ,Cys C)水平及其与血肌酐、内生肌酐清除率的相关性 ,评价血清胱抑素C在评估肾小球滤过功能中的意义。方法 :采用ELISA法测定 13 3例肾病患者的血清胱抑素C水平 ,并与血肌酐、内生肌酐清除率作相关性分析。结果 :血清胱抑素C与血肌酐之间呈高度正相关 (r =0 .774,P <0 .0 1) ,与内生肌酐清除率之间存在高度负相关 (r =-0 .82 3 ,P <0 .0 1)。在肾功能损害早期血清胱抑素C改变较血肌酐更敏感 (P <0 .0 1)。结论 :血清胱抑素C在肾病患者肾功能不同损害期均能准确反映肾小球滤过功能 ,尤其能敏感提示早期肾功能损害 。
出处 《广东医学院学报》 2004年第2期137-138,共2页 Journal of Guangdong Medical College
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