摘要
目的:探讨健心汤对充血性心力衰竭(CHF)患者血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、一氧化氮(NO)水平的干预作用。方法:将66例CHF患者随机分为试验组和对照组。对照组采用常规治疗,试验组在常规治疗的基础上加用健心汤。两组疗程均为4周。治疗前后测定TNF-α、IL-6、NO和心功能的变化。结果:治疗后两组血清TNF-α、IL-6、NO水平均明显下降,试验组较对照组降低更为显著(P<0.05)。治疗后两组心功能均有改善(P<0.05或P<0.01),但试验组作用优于对照组。结论:健心汤可能通过调控细胞因子的水平,起到防止和逆转心室重构、改善心功能的作用。
Objective: To investigate intervenient actions of Jianxin Decoction on serum level of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and nitric oxide (NO) in the patient of congestive heart failure (CHF). Methods: 66 cases of CHF were randomized to trial group and control group. 33 cases in each. Control group received routine treatment and the trial group was treated by routine treatment plus Jianxin Decoction for 4 weeks. TNF-a. IL-6 and NO level and cardiac function before and after treatment were investigated. Results: After treatment, serum TNF-a. IL-6 and NO level in both groups were significantly decreased with the trial group decreased more significantly (P< 0. 05). and the cardiac function significantly improved (P<0. 05 or P<0. 01) with the trial group being superior to the control group. Conclusion: Jianxin Decoction can adjust level of cytokines and can prevent and reverse ventricular remodeling and improve cardiac function in the patient of CHF.
出处
《中医杂志》
CSCD
北大核心
2004年第3期186-187,194,共3页
Journal of Traditional Chinese Medicine
