摘要
目的 探讨鼻腔鼻窦的非霍奇金淋巴瘤 (non Hodgkin’slymphoma ,NHL)的临床特征、免疫表型及与埃 巴二氏病毒 (Epstein Barrvirus ,EBV)的关系。方法 回顾性分析了 40例鼻腔鼻窦NHL的临床特征 ,应用免疫组化方法观察了免疫表型 ,以原位杂交技术检测T细胞淋巴瘤的EBV情况。结果 鼻腔鼻窦NHL临床上多以鼻阻、涕血为首发症状 ,确诊则主要依靠病理组织学形态。鼻腔鼻窦NHL的免疫表型显示T细胞来源占 90 0 %( 3 6/4 0 ) ,B细胞来源占 10 0 %( 4 /4 0 )。T、B细胞淋巴瘤EBER检出率 75 0 %( 2 7/3 6) ,B细胞淋巴瘤EBER检出率 2 5 0 %( 1/4 )。结论 鼻腔鼻窦NHL发病与多因素有关 ,其临床特征缺乏特异性。鼻腔鼻窦NHL多来源于T细胞 。
Objective To study the clinical features, immunophenotype of non Hodgkin's lymphoma(NHL) and the correlation with Epstein Barr virus(EBV) infection in nasosinus. Methods Clinical features of 40 patients with T cell lymphomas in the nasosinus were analyzed retrospectively. The immunophenotype was observed by immunohistochemical methods, and Epstein Barr virus infection was detected by in situ hybridization technique. Results Rhinostegnosis and rhinorragia were the first symptoms in patients with NHL in the nasosinus. The confirmative diagnosis was dependent on histopathology. Immunophenotype of NHL revealed that sinonasal lymphomas were originated from T cell (36/40, 90 0%) and B cell (4/40, 10 0%). The detection rates of T cell lymphomas and B cell lymphomas were 75 0% (27/36) and 25.0% (1/4), respectively. Conclusion Many factors are involved in the cause of the NHL in the nasosinus, but its clinical features are not of specificity. NHL in the nasosinus mostly originates from T cell. Sinonasal T cell lymphomas may be closely correlated with EBV.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第4期341-343,共3页
Journal of Third Military Medical University
