摘要
目的 了解吸入一氧化氮 (NO)对急性高原病患者血浆血栓素B2 (TXB2 )和 6 酮 前列腺素F1a( 6 Keto PGF1a)变化及临床症状的影响。方法 47例急性高原病患者随机分为 2组 ,一组为常规药物治疗组 ( 2 3例 ) ,另一组为NO治疗组 ( 2 4例 )。常规药物治疗组给予吸氧、氨茶碱、地塞米松、速尿等药物治疗。NO治疗组仅给予吸入由海拔 3 65 8m高度空气平衡的 0 .0 0 1%的NO气体 ,每天 2次 ,上午、下午各 1h。观察两组治疗前后血浆TXB2 和 6 Keto PGF1a含量及临床症状的变化情况 (临床症状采用LakeLouise急性高原病评分规则评分 )。结果 两组患者治疗前后相比TXB2 、TXB2 /6 Keto PGF1a及临床症状评分均显著下降 ,6 Keto PGF1a显著升高 ,其中常规药物治疗组P <0 0 5 ,NO治疗组P <0 0 1;两组治疗后比较P <0 0 5。结论 吸入NO能使急性高原病患者血浆TXB2 和TXB2 /6 Keto PGF1a比值显著降低 ,6 Keto PGF1a显著升高 ,并显著改善急性高原病患者的临床症状 ,有利于患者康复。
Objective To observe the effects of inhalation of nitric oxide (NO) on serum thromboxane B 2 (TXB 2) and 6 keto prostaglandin F 1a (6 keto PGF 1a ) in plasma of patients with acute high altitude illness. Methods A total of 47 patients with acute high altitude illness were randomized into two groups: routine treatment group (23 patients), treated with oxygen inhalation, aminophylline, dexamethasone, and furosemide, etc; and NO treatment group (24 patients), treated with inhalation of air balanced 0.001% NO from altitude 3 658 meters twice a day (one time for 1 h in the morning and in the afternoon, respectively). The changes of TXB 2 and 6 keto PGF 1a contents in plasma of patients and the clinical symptoms (based on the rules of Lake Louise for symptom scoring of patients with high altitude illness) of patients in the two groups were observed. Results Compared with those in the two groups before treatment, TXB 2 contents, TXB 2/6 Keto PGF 1a , and symptom scores decreased significantly, but 6 keto PGF 1a increased significantly ( P <0.05). Conclusion NO inhalation can markedly decrease TXB 2 content and TXB 2/6 keto PGF 1a in plasma of patients with acute high altitude illness, increase 6 keto PGF 1a and markedly improve the clinical symptoms of patients, so it is helpful for the recovery of acute high altitude illness.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第5期441-443,共3页
Journal of Third Military Medical University
