摘要
目的 对 11例脾原发性恶性淋巴瘤 (PLS)进行临床病理及免疫组化研究。方法 对瘤组织进行常规HE染色及SP法免疫组化染色 ,光镜观察。结果 11例患者以左上腹疼痛和巨脾为主要症状。 11例瘤细胞CD45均(+ ) ;10例B细胞性淋巴瘤CD2 0 (+ ) ,其中B小淋巴细胞性淋巴瘤 3例 ,CD43、CD79α和bcl 2 (+ ) ;脾边缘区B细胞性淋巴瘤 3例 ,CD79α、IgM、ALK(+ ) ,IgD(± ) ;淋巴浆细胞样淋巴瘤 2例 ,CD43、CD79α、bcl 2 (+ ) ,IgD(-) ;弥漫性大B细胞性淋巴瘤 2例 ,ALK(+ ) ,CD3 0、CD3 (± )。 1例周围T细胞性淋巴瘤 ,无其他特征型CD45RO和CD3 (+ ) ,CD3 0 (± )。结论 PLS较罕见 ,应与脾内其他原发性或继发性小细胞性恶性肿瘤鉴别 ,免疫组化染色对诊断。
ObjectiveTo investigate the characteristics of c linicopathology and immunohistochemical findings of primary lymphoma of spleen (PLS) in 11 cases, together wi th review the literature MethodsThe routine paraffin sections were prepared, and stained with HE and immunochemistry of ABC method, and observed under optical microscope ResultsThe average age of the 11 patients was 49 4 The tumor were prevalent in men (8/11 cases) The tumors were predominantly B c ell lymphoma (10/11 cases) and occasionally T cell one (1/11 cases) On the immuno chemically stained sections, the tumor cells of all the 11 cases expressed LCA, in which 10 cases expressed CD20, and 1 case CD45RO, repectively ConclusionsThe PLB is relatively rare It should be differentiated from other primary or metastatic small cell malignant tumors of spleen Immunoh istochemical staining plays a crucial role in diagnosis, differential diagnosis, t yping of PLS, and histogenetic analysis of the tumor Most of PLS is B cell Ly mphoma originated from B lymphocytes in bone marrow
出处
《诊断病理学杂志》
CSCD
2004年第1期15-17,I004,共4页
Chinese Journal of Diagnostic Pathology
