摘要
目的 :探讨细胞间黏附分子 1(ICAM 1)、白细胞介素 6 (IL 6 )在变应性鼻炎鼻及支气管黏膜中的表达及意义。方法 :采用免疫组织化学方法检测ICAM 1、IL 6在 2 8例变应性鼻炎患者 (鼻炎组 )及 12例健康志愿者 (对照组 )的鼻、支气管黏膜中的表达。结果 :ICAM 1在鼻炎组鼻和支气管黏膜中的表达率分别为 10 0 .0 0 %和92 .86 % ,其差异无统计学意义 (P >0 .0 5 ) ;对照组鼻、支气管黏膜中ICAM 1表达率 (分别为 6 6 .6 7%和 5 8.33% )分别与鼻炎组 (分别为 10 0 .0 0 %和 92 .86 % )比较 ,差异均有统计学意义 (分别P <0 .0 1和P <0 .0 5 )。IL 6在鼻炎组鼻、支气管黏膜中的表达率分别为 10 0 .0 0 %、82 .14 % ,其差异无统计学意义 (P >0 .0 5 ) ;对照组鼻、支气管黏膜中IL 6表达率均为 4 1.6 7% ,分别与鼻炎组 (分别为 10 0 .0 0 %和 82 .14 % )比较 ,差异均有统计学意义 (分别P<0 .0 1和P <0 .0 5 )。结论 :ICAM 1、IL 6是呼吸道变态反应性炎症中的重要细胞因子 ,上、下呼吸道变应性炎症密切相关 ;同时治疗上、下呼吸道炎症性疾病 ,才能取得更好的治疗效果。
Objective:To investigate the expression and its significens of intercellular adhesion molecule-1 (ICAM-1) and interleukin-6 (IL-6) in nasal and bronchial mocosa in allergic rhinitis.Method:Samples of nasal and bronchial mucosa were from 28 patients with allergic rhinitis and 12 controls and their paraffin sections were studied with immuno histochemical technique staining with ICAM-1 monoclonal antibodies and IL-6 polyclonal antibodies.Result:The positive expression percentage of ICAM-1 in mucosa of nasal and bronchial in patients with allergic rhinitis were 100% and 92.86%. No difference were observed between them, P>0.05. But in the group of controls, those were obviously lower(66.67% and58.33%).The difference between them was significant,P<0.05. The positive expression percentage of IL-6 in mucosa of nasal and bronchial in patients with allergic rhinitis were 100% and 82.14%. No difference were observed between them, P>0.05. But in the group of normal controls, those were obviously lower(41.67% and 41.67%). The difference between them was significant,P<0.05.Conclusion:ICAM-1 and IL-6 are important cytokines in the allergic inflammation in airway. The closely correlation was observed between the allergic inflammation in upper and lower airway,so that the upper and lower airway should be treated as a united one. To otorhinolaryngologists and respiratory doctors, it is safe and efficient treatment to treat the inflammatory diseases in upper and lower airway at the same time.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2004年第5期261-263,T008,共4页
Journal of Clinical Otorhinolaryngology
