摘要
报告一例十分罕见的肾小球内癌转移病例。肾活检标本进行了光镜、免疫荧光、免疫组化及透射电镜检查。组织学观察,肾小球毛细血管内异常细胞堆积。免疫荧光结果:异常细胞IgG,IgA,IgM,C3,C1q,FRA,ALb,k链及λ链均阴性。免疫组化染色异常细胞LCA及F8阴性,chromogranin阳性。电镜观察异常细胞胞质内含特征性的致密核心颗粒。病理诊断神经内分泌癌肾小球内转移。上述结果显示,电镜检查及免疫组织化学方法对本例有诊断意义。
We report one rare case with intraglomerular carcinoma metastasis . Renal biopsy specimen was examined by light microscopy, immunofluorescence, immunohistochemistry and transmission electron microscopy. Histologically, abnormal cells stacked within glomerular capillary lumina. Immunofluorescence result:abnormal cells showed all negative staining for IgG, IgA, IgM, C_3, C_(1q), FRA, ALb, κ and λ. Immunohistochemistry showed negative staining for LCA and F_8, but positive express for chromogranin. Ultrastructurally, abnormal cells contained characteristic dense-core granules. The pathologic diagnosis was intraglomerular metastasis of neuroendocrine carcinoma. These results suggest that electron microscopic and immunohistochemical techniques are of great value in the diagnostic pathology.
出处
《电子显微学报》
CAS
CSCD
北大核心
2004年第1期32-35,共4页
Journal of Chinese Electron Microscopy Society
