摘要
[目的]探讨内皮细胞特异性分子1(ESM鄄1)在肾癌中的表达及其意义。[方法]应用免疫组织化学S鄄P法检测52例肾癌、32例癌旁正常肾组织中ESM鄄1的表达,并与CD34进行比较。[结果]ESM鄄1在正常肾组织与肾癌中均有表达。主要表达于血管内皮,部分表达在肾小管上皮和肾癌细胞。肾癌血管内皮的ESM鄄1表达率(50%)显著高于正常肾组织的血管内皮(0.06%)(P<0.001);ESM鄄1的表达在正常肾小管上皮细胞与肾癌细胞无显著差异;ESM鄄1在肾颗粒细胞癌中的高表达率为63.16%,明显高于在肾透明细胞癌中的表达(21.21%)(P<0.01),而与肿瘤的组织学分级、淋巴结转移和肿块大小无明显差异。肾癌间质血管ESM鄄1和CD34的表达呈正相关(r=0.452,P<0.001)。[结论]ESM鄄1表达可能与肾癌的血管生成及发生、发展有关,ESM鄄1可作为血管内皮的潜在标志物,并有可能作为肾癌的辅助诊断及预后判断的参考指标。
To investigate the expression and clinical significance of endothelial cell specific molecule-1 (ESM-1) in renal cell carcinoma.ESM-1 was detected by immunohistochemical S-P method in 52 cases of renal carcinoma and in 32 normal renal tissues adjacent to neoplastic lesions,which were compared to the expression of CD34.ESM-1 which was mainly located in vascular endothelia and partially in epithelia of renal tubule and carcinoma cells,was found both in renal carcinoma and in normal renal tissue.The expression rate of ESM-1 in the endothelia of renal carcinomas(50%) was significantly higher than that in the normal renal tissue(0.06%)(P<0.001).There was no difference between the expression of ESM-1 in normal renal tubule epithelia and in the cancer cells.Significant difference was found between ESM-1 expression in granular cell carcinoma(63.16%) and in clear renal cell carcinoma(21.21%)(P<0.01), but the expression of ESM-1 was not correlated to histological grading,lymphnode involvement and tumor size.Positive correlation was discored between the expressions of ESM-1 and CD34(r=0.452,P<0.001).[Conclusions]Expression of ESM-1 is related to angiogenenesis,occurrence and development of renal cell carcinoma. ESM-1 could be used as a marker of vascular endothelium,and might be a feature of diagnosis and prognosis of renal carcinoma.
出处
《中国肿瘤》
CAS
2004年第5期309-312,共4页
China Cancer
基金
国家自然科学研究基金(39870324)
安徽省人事厅跨世纪学术带头人研究基金
安徽省教育厅自然科学基金(2003kj184)资助
关键词
内皮细胞特异性分子1
肾肿瘤
免疫组织化学
endothelial cell specific molecule-1
kidney neoplasms
immunohistochemistry
