摘要
目的 观察托吡酯添加治疗小儿难治性癫痫的疗效及安全性。方法 对 4 0例小儿难治性癫痫在原用药物基础上添加托吡酯治疗 ,开放性自身前后对照。结果 4 0例患儿显效 2 6例(6 5 % ) ,好转 7例 (17.5 % ) ,无效 7例 (17.5 % )。表现为全身性发作癫痫 2 4例 ,显效 12例 (80 % ) ,好转 2例 (13.3% ) ;继发性癫痫 9例 ,显效 5例 (5 5 .6 % ) ,好转 2例 (14 .3% ) ;表现为部分性发作癫痫 14例 ,显效 9例 (6 4.3% ) ,好转 2例 (14 .3% ) ;不能分类的癫痫发作 2例 ,好转 1例。全身性发作癫痫的显效率高 ,但与其他类型比较差异无显著性 (P >0 .0 5 )。全身性发作癫痫的病例中 ,原发性癫痫显效率最高 ,但与继发性癫痫比较差异无显著性 (P >0 .0 5 )。观察病例中仅 4例有轻微不良反应。结论 托吡酯添加治疗小儿难治性癫痫疗效显著 ,安全性好 ,副作用小。
Objective To observe the therapeutic effect and safety of the addition of topiramate in treating intractable epilepsy.Methods Topiramate was added to the formerly used medicine in treating 40 cases of intractable epilepsy in children.Open comparison of each case was conducted before and after treatment.Results Remarkable effects were got in 26 cases (65%),relative improvements in 7cases(17.5%) and no effect in other 7 cases (17.5%).12(80%) of the 24 cases of generalized seizure got remarkable improvement,and 2 cases (13.3%)got slight effect.Among the 9 cases of secondary epilepsy,5 cases (55.6%) got remarkable effect and 2 cases (14.3%) slight effect.Among the 14 cases of partial epilepsy,9 cases (64.3%) got remarkable effect and 2 cases (14.3%) some effect.One of the two cases that could not be classified got improved.The rate of remarkable effect was higher in cases of generalized seizure than in other cases,but there was not significant difference when compared with other types (P>0.05).The rate of remarkable effect on the primary attacks was the highest,but there was no significant difference when compared with secondary epilepsy (P>0.05).Only 4 of the observed cases got slight side effects.Conclusion The addition of topiramate in the treatment of intractable epilepsy in children is safe and has remarkable effects with only few side-effects.
出处
《临沂医学专科学校学报》
2004年第2期117-119,共3页
Journal of Linyi Medical College
关键词
托吡酯
难治性癫痫
儿童
Topiramate
Intractable epilepsy
Child
