摘要
目的 :探讨氧自由基 (OFR)在急性病毒性心肌炎 (AVMC)发病中的作用及硒 (Se)制剂对 OFR损伤心肌的治疗作用。方法 :将 6 0例患儿作为 VMC组 ,6 0例健康儿童作为对照组。测定两组血硒 (Se)、谷胱甘肽过氧化物酶 (GSH- PX)、超氧化物歧化酶 (SOD)、丙二醛 (MDA )水平。将 6 0例 AVMC患儿随机分为补硒组 (30例 )和常规治疗组 (30例 )。补硒组 30例在心肌炎常规治疗 (抗病毒、调节免疫、能量合剂、维生素 C营养心肌 )基础上补硒治疗 ,常规治疗组 30例给予心肌炎常规治疗 ,疗程 4周。观察两组治疗前后血 Se、 GSH - PX、SOD、 MDA ,并结合心肌酶、心电图、临床表现进行疗效判定。结果 :AVMC患儿体内的氧自由基反应和脂质过氧化反应呈病理性变化。 6 0例 AVMC患儿血 Se、 SOD、 GSH- PX降低 (P<0 .0 0 1 ) ,MDA值升高 (P<0 .0 0 1 ) ,补硒组治疗后较治疗前血 Se、SOD、GSH- PX 明显升高 (P<0 .0 1、P<0 .0 1、P<0 .0 0 1 ) ,MDA值明显降低 (P<0 .0 0 1 ) ,临床症状全部消失 ,心肌酶恢复正常 ,心电图恢复正常百分率明显高于常规治疗组 (P<0 .0 5 )。结论 :Se通过清除氧自由基 ,抑制脂质过氧化反应而保护心肌 ,提高 AVMC患儿治愈率 ,在常规治疗基础上加
Objective To study the action of oxygen free radical (OFR) in pathogenesis of acute viral myocarditis (AVMC) and the therapeutic effect of selenium (Se) on myocardium damaged by OFR. Methods Se in serum, superoxide dismutase (SOD), glutathione peroxidase (GSH P X),malonadelye (MDA) were detected in children, which included 60 cases of AVMC children and 60 healthy children as control, respectively. Children with AVMC were randomly divided into routine treatment group (30 cases) and Se supplemented group (30 cases). Se supplemented and routine treatment (anti viruses, immune system modulation, myocardium nourishing) were used in Se supplemented group. Only routine treatment was used in routine treatment group. The treatment period was 4 weeks. Through observation of changes of Se in serum, GSH P X,SOD,MDA,enzyme of myocardium, ECG and clinical symbols before and after treatment in two groups, the curative effects were assessed. Results OFR and LPO reactions appeared pathological changes in children with AVMC. Se in serum,SOD,GSH P X were decreased ( P <0 001) and MDA was increased ( P <0 001) in children with AVMC. After treatment with Se supplemented, Se in serum, SOD,GSH P X activities were significantly increased ( P<0 01, P<0 01, P <0 001)and MDA content was significantly decreased ( P <0 001), compared with before treatment, and all of the clinical symbols were disappeared. Enzymes of myocardium were normal. The percentage of ECG normalization was significantly higher than that of the routine treatment group ( P <0 05). The curative rate of AVMC was increased. Conclusion Se is effective to clear OFR and able to protect myocardium through inhibiting OFR and LPO reaction. On the basis of routine treatment for viral myocarditis, Se supplemented is more effective than routine treatment.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2004年第3期437-440,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省卫生厅科研基金资助课题 (980 1 6 )
关键词
硒
心肌炎
脂质过氧化作用
活性氧
Selenium
myocarditis
Lipid peroxidation
reactive oxygen species
