摘要
目的探讨前列腺素E1穴PGE1雪对周围神经再生的作用并与维生素B1、B6的疗效相比较。方法将22例前臂神经损伤的患者穴正中神经10根,尺神经12根雪熏根据年龄、性别、神经种类、损伤平面、损伤时间至修复间隔时间相同或相近配对,随机分为2组,PGE1组:神经缝合术后应用PGE150μg加入0.9%生理盐水500ml静点,每日一次,连续用药1个月;B族维生素组:神经缝合术后口服维生素B1、B6各10mg/次,每日一次,连续用药三个月。术后平均随访7个月,经肌电图检测,测定神经运动电位、感觉电位的潜伏期和波幅。结果两组相比,除正中神经运动电位潜伏期和尺神经感觉电位波幅无明显差异外,其余各指标PGE1组均优于B族维生素组。结论前列腺素E1对周围神经损伤的恢复有促进作用。
Objective To investigate the effect of prostaglandinE1on peripheral nerve regeneration and compare it with that of vitaminB 1 and B 6 . Methods According to the time of hospitalization,we randomly divided22cases with nerve injuries at forearm into two groups.Group A were treated with Vit B 1 /B 6 and group B with prostaglandinE 1 postoperatively.All patients were followed-up fomr4to12months,with an average of7months,and we detected nerve regeneration,eletrophysiological examinations including EMG,CMAP and SNAP,and the latency,amplitude of action potential were measured. Results All results,except the CMAP latency of median nerve and the SNAP amplitude of ulnar nerve,showed better nerve regeneration in group A than that of in group B. Conclusion ProstaglandinE 1 can promote peripheral nerve regeneration.
出处
《实用手外科杂志》
2004年第2期84-86,共3页
Journal of Practical Hand Surgery
