摘要
研究血清学指标预测慢性乙型肝炎 (简称慢乙肝 )肝组织病变程度的可靠性 ,探讨慢乙肝的临床诊断与病理诊断的符合度。对 10 5例慢乙肝患者的肝穿组织进行炎症活动度分级 (G)及纤维化程度分期 (S) ,并定量检测血清中的ALT、AST、A/G、GGT、PTA及HBVDNA。对慢乙肝的临床诊断与病理诊断进行对照。血清ALT、AST、A/G、GGT、PTA在各级各期慢乙肝中的差异无显著意义 (P <0 0 5 )。HBVDNA定量在各级各期慢乙肝中的差异无显著意义 (P >0 0 5 )。慢乙肝的临床诊断与病理诊断的符合率 ,慢肝轻度 96 8%、慢肝中度 5 0 0 %、慢肝重度 7 7%。血清ALT、AST、A/G、GGT、PTA可作为慢乙肝肝组织病变程度的预测指标 ,而血清HBVDNA水平不能作为慢乙肝肝组织病变程度的预测指标。临床诊断慢性肝炎中重度患者应行肝组织病理检查 ,尽可能使临床诊断与病理诊断相符。
To study the dependable of serum indexes estimating liver build up pathological changes degree in chronic hepatitis B. to evaluate the concordance between clinical diagnosis with pathological diagnosis in chronic hepatitis B. hepatic histological findings were diagnosed by liver inflammation grades(G) and fibrosis stages(S). We examined the serum levels of ALT、AST、A/G、GGT、PTA、HBVDNA and compared clinical diagnosis with pathological diagnosis in 105 patients with chronic hepatitis B. serum ALT、AST、A/G、GGT、PTA Were significane difference in the each period of grades and stages (P<0.05). HBVDNA were not difference in the each preiod of grades and stages in chronic hepatitis B (P>0.05). accordance of the mild, medium and severe changes was 96.8%、50.0% and 7.7%. Serum ALT、AST、A/G、GGT、PTA may be used as the estimate indexes to organize pathological changes degree. but serum HBVDNA may not be used as the estimate indexes to organize pathological changes degree. The patients with clinical medium severe have to do pathological examination, possibly make the clinical diagnosis agree with pathology diagnosis.
出处
《临床肝胆病杂志》
CAS
北大核心
2004年第3期153-154,共2页
Journal of Clinical Hepatology
关键词
慢性乙型肝炎
检测
病理分类
诊断
血清学指标
chronic hepatitis B
serum features
pathological grading
clinical diagnosis
