摘要
<strong>Objective: </strong><span style="font-family:;" "=""><span style="font-family:Verdana;">Despite the growing evidence that lipopolysaccharide binding protein (LBP) plays a major role in cardiovascular disease (CVD) pathophy</span><span style="font-family:Verdana;">siology and obesity, data regarding this association in children are rar</span><span style="font-family:Verdana;">e. Therefore, our objectives were to assess whether there was a difference between overweight/obese and normal-weight children in plasma LBP levels and to assess the cardiovascular changes in both groups.</span></span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">In an observational, case-control study, a total of 30 children as obese and overweight children.</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">Obese children with body mass index (BMI) above 95</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> percentile, and overweight children with BMI between 85</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> and 95</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> percentile were recruited if they aged between 8-16 years old.</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">A similar number of matched controls were included. Serum LBP was measured by enzyme-linked immunosorbent assay (ELISA) technique. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">With regard to serum LBP, the mean LBP was significantly higher in obese children than </span><span style="font-family:Verdana;">in </span><span style="font-family:Verdana;">the control group (52.74 ± 17.25 versus 12.34 ± 2.67</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">μg/mL, respectively;p <</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.001). The ROC curve showed that the serum LBP, at a cutoff value of >19</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">μg/mL, was </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">significant discriminator of obesity with a sensitivity of 96.67% and specificity of 100%. The regression analysis showed that BMI was</span><span style="font-family:Verdana;"> an</span><span style="font-family:Verdana;"> independent predictor of serum LBP (B coefficient = 0.684;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.024).</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">The serum LBP correlated significantly with age (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.58;p = 0.001), BMI (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.834;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.001), and LV longitudinal strain (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.362;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05).</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Conclusion</span></b><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">In conclusion, our findings showed that obesity was associated with</span><span style="font-family:Verdana;"> a</span><span style="font-family:Verdana;"> worse lipid profile and cardiovascular function. LBP is a promising predictor </span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> obesity in children.</span>
<strong>Objective: </strong><span style="font-family:;" "=""><span style="font-family:Verdana;">Despite the growing evidence that lipopolysaccharide binding protein (LBP) plays a major role in cardiovascular disease (CVD) pathophy</span><span style="font-family:Verdana;">siology and obesity, data regarding this association in children are rar</span><span style="font-family:Verdana;">e. Therefore, our objectives were to assess whether there was a difference between overweight/obese and normal-weight children in plasma LBP levels and to assess the cardiovascular changes in both groups.</span></span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">In an observational, case-control study, a total of 30 children as obese and overweight children.</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">Obese children with body mass index (BMI) above 95</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> percentile, and overweight children with BMI between 85</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> and 95</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> percentile were recruited if they aged between 8-16 years old.</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">A similar number of matched controls were included. Serum LBP was measured by enzyme-linked immunosorbent assay (ELISA) technique. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">With regard to serum LBP, the mean LBP was significantly higher in obese children than </span><span style="font-family:Verdana;">in </span><span style="font-family:Verdana;">the control group (52.74 ± 17.25 versus 12.34 ± 2.67</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">μg/mL, respectively;p <</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.001). The ROC curve showed that the serum LBP, at a cutoff value of >19</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">μg/mL, was </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">significant discriminator of obesity with a sensitivity of 96.67% and specificity of 100%. The regression analysis showed that BMI was</span><span style="font-family:Verdana;"> an</span><span style="font-family:Verdana;"> independent predictor of serum LBP (B coefficient = 0.684;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.024).</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">The serum LBP correlated significantly with age (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.58;p = 0.001), BMI (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.834;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.001), and LV longitudinal strain (r =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.362;p =</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05).</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Conclusion</span></b><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">In conclusion, our findings showed that obesity was associated with</span><span style="font-family:Verdana;"> a</span><span style="font-family:Verdana;"> worse lipid profile and cardiovascular function. LBP is a promising predictor </span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> obesity in children.</span>
