摘要
为了探索杀菌剂辛唑嘧菌胺的工艺路线和合成方法,并寻找一条适用于工业化生产的路线。以丙酰乙酸甲酯和溴代正辛烷为原料,经过取代、环合、氯化、胺化4步反应合成了目标化合物辛唑嘧菌胺。反应总收率为31.2%,含量为96.8%,产物经1H NMR进行表征。该方法操作简单,条件温和,适用于工业化生产。
This article isaimedto explore the manufacturing process and synthesis method of fungicide ametoctradin and establish a reasonable route forindustrial scale production.The target compound ametoctradin was produced by four steps including substitution,cyclization,chlorination and ammoniation.The method has advantages of simple operation and mild condition,which is suitable for industrialized production.The total reaction yield reached 31.2%and the purity was 96.8%.The final product was identified by ~1H NMR.
出处
《农药科学与管理》
CAS
2016年第12期-,共5页
Pesticide Science and Administration
