本文主要研究了页岩气分簇式射孔技术及其复杂故障控制方法。首先概述了页岩气开发现状与分簇式射孔技术应用现状。接着详细分析了页岩气分簇式射孔复杂故障类型及成因,探讨了技术、操作、设备与维护等方面导致故障的因素。根据复杂故...本文主要研究了页岩气分簇式射孔技术及其复杂故障控制方法。首先概述了页岩气开发现状与分簇式射孔技术应用现状。接着详细分析了页岩气分簇式射孔复杂故障类型及成因,探讨了技术、操作、设备与维护等方面导致故障的因素。根据复杂故障原因探讨了故障预防策略、故障诊断技术以及故障处理与应对措施,提出设备优化射孔方案设计、实时监测与预警系统等预防策略,以及针对不同故障的处理方法。之后阐述了复杂故障控制方法的实施流程、实施过程中的关键问题与解决方案。最后总结了研究成果,并对未来研究方向进行了展望。This paper mainly studies the shale gas cluster perforation technology and its complex fault control methods. Firstly, it outlines the current status of shale gas development and the application status of cluster perforation technology. Then, it analyzes in detail the types and causes of complex faults in shale gas cluster perforation, and discusses the factors leading to faults in terms of technology, operation, equipment, and maintenance. Based on the causes of complex faults, strategies for fault prevention, fault diagnosis technology, and fault handling and response measures are discussed. Proposals include equipment optimization perforation scheme design, real-time monitoring and early warning systems, as well as handling methods for different faults. Subsequently, the implementation process of the complex fault control method, key issues in the implementation process, and solutions are described. Finally, the research results are summarized, and the future research directions are prospected.展开更多
背景:血管阻力(VR)指的是血液在流经血管过程中所遇到的阻力。这是一种在正常血液循环和心脏功能中发挥关键作用的生理现象。然而,异常的血管阻力是多种循环系统疾病和心血管病理状态的基础。尽管近年来对血管阻力展开了广泛研究,但迄...背景:血管阻力(VR)指的是血液在流经血管过程中所遇到的阻力。这是一种在正常血液循环和心脏功能中发挥关键作用的生理现象。然而,异常的血管阻力是多种循环系统疾病和心血管病理状态的基础。尽管近年来对血管阻力展开了广泛研究,但迄今为止尚未有相关的文献计量分析。本研究旨在阐明血管阻力研究的发展趋势和新兴焦点,为未来的研究以及基于证据的决策提供指导。方法:所有相关文献均从Web of Science核心合集(WoSCC)数据库中获取。采用HistCite、CiteSpace和VOSviewer对文献进行计量分析和可视化处理。结果:本研究的主要学科领域为“生物学与医学”。共纳入6645篇与“血管阻力”相关的英文文献,年度发表数量呈现稳定趋势。美国在发表文献数量和引用量上均位居第一。产出最多的机构、期刊和作者分别为Mayo Clinic、Pulmonary Circulation和Marc Humbert;而引用量最高的期刊和作者则分别为International Journal of Cardiology和Simonneau,Gerald。伦敦帝国学院在机构间的合作最为广泛。在聚类分析中,“心力衰竭”(聚类0#)为最大的聚类。此外,“肺动脉高压”、“血压”和“血管阻力”为主要关键词,而“社会”和“性别差异”则是近年来出现的最新突现关键词。结论:肺动脉高压可能成为血管阻力领域的新兴热点,这在一定程度上与2019冠状病毒病(COVID-19)与肺动脉高压之间的关联有关。近期在慢性血栓栓塞性肺动脉高压(CTEPH)研究中的进展,有助于深入理解肺部疾病的发病机制和治疗策略。此外,血管阻力监测技术在心血管疾病的诊断和管理中具有重要的临床意义。Background: Vascular Resistance (VR) refers to the resistance encountered by blood flow as it moves through the blood vessels. It is a physiological phenomenon that plays a vital role in normal blood circulation and heart function. Nonetheless, aberrant vascular resistance underlies various circulatory disorders and cardiovascular pathologies. Despite extensive investigations of VR in recent years, no bibliometric analysis has been conducted thus far. The objective of this is to elucidate the evolutionary trends and emerging focal points within VR research while offering guidance for future investigations and evidence-based decision-making. Methods: All the relevant literature was obtained from the Web of Science Core Collection (WoSCC) database. HistCite, CiteSpace, and VOSviewer were employed to perform bibliometric analysis and visualization. Results: “Biology and Medicine” is the main research categories in this research. A total of 6645 English documents related to “Vascular Resistance” were included. The number of annual publications shows a stable trend. The United States is the country with the largest publications and the largest citations. The most productive institution, journal, and author are Mayo Clinic, Pulmonary Circulation, Marc Humbert, respectively. The most highly cited journal and author are International Journal of Cardiology, and Simonneau, Gerald. Imperial College London had the most extensive collaboration among the institutions. In clustering analysis, “heart failure” (cluster 0#) is the largest cluster. Moreover, “pulmonary hypertension”, “blood pressure”, and “vascular resistance” are the primary keywords. “Society” and “sex difference” are the newest burst keywords in recent years. Conclusion: Pulmonary hypertension may become an emerging hotspot in the field of VR, partly because of the link between Corona Virus Disease 2019 and pulmonary hypertension. Recent advances in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) research help understand the pathogenesis and treatment of lung diseases. In addition, VR monitoring technique has important clinical significance for the diagnosis and management of cardiovascular diseases.展开更多
多囊卵巢综合征(polycystic ovary syndrome, PCOS)和桥本甲状腺炎(Hashimoto’s thyroiditis, HT)均为育龄期女性常见的内分泌代谢紊乱性疾病。临床观察发现,PCOS与HT具有相似的临床表现。近年来,越来越多的研究证实,PCOS女性中HT的发...多囊卵巢综合征(polycystic ovary syndrome, PCOS)和桥本甲状腺炎(Hashimoto’s thyroiditis, HT)均为育龄期女性常见的内分泌代谢紊乱性疾病。临床观察发现,PCOS与HT具有相似的临床表现。近年来,越来越多的研究证实,PCOS女性中HT的发生率明显高于一般人群,二者共病将进一步加重生殖障碍和代谢紊乱。提示这两种疾病之间可能存在某种关联,但内在的病理生理机制尚不清楚。探讨PCOS与HT之间的相互关系对PCOS的临床管理具有重要意义。PCOS and HT are common endocrine and metabolic disorders in women of childbearing age. Clinical observations show that PCOS and HT have similar clinical manifestations. In recent years, more and more studies have confirmed that the incidence of HT in women with PCOS is significantly higher than that in the general population, and the comorbidity of the two further aggravates reproductive disorders and metabolic disorders. It is suggested that there may be some correlation between the two diseases, but the underlying pathological and physiological mechanism is still unclear. It is of great significance to explore the interrelationship between PCOS and HT for the clinical management of PCOS.展开更多
对于中医流派传承模式的不断探索,是中医流派生存与发展的必经之路。本文以介绍谢氏正骨流派在自身发展中逐步形成的传承模式,探讨传承模式对中医流派发展的影响。基于以下几点:首先需要强化流派“导师”团队建设,其次需要优化流派内部...对于中医流派传承模式的不断探索,是中医流派生存与发展的必经之路。本文以介绍谢氏正骨流派在自身发展中逐步形成的传承模式,探讨传承模式对中医流派发展的影响。基于以下几点:首先需要强化流派“导师”团队建设,其次需要优化流派内部人才培养模式,最后需要完善流派传承管理制度。The continuous exploration of the inheritance mode of traditional Chinese medicine schools is a necessary path for the survival and development of traditional Chinese medicine schools. This article introduces the inheritance model gradually formed by Xie’s Orthopedic School in its own development, and explores the impact of inheritance models on the development of traditional Chinese medicine schools. Based on the following points: Firstly, it is necessary to strengthen the construction of the “mentor” team of the school. Secondly, it is necessary to optimize the internal talent training mode of the school. Finally, it is necessary to improve the school inheritance management system.展开更多
卵巢癌是全球女性生殖系统中死亡率最高的一种恶性肿瘤,多数患者初次诊断即为晚期。现有的治疗方案是肿瘤细胞减灭术并辅以铂类为基础的联合化疗,但容易出现耐药和复发,因此迫切需要开发新的治疗方案。铁死亡是近年来发现的一种调节性...卵巢癌是全球女性生殖系统中死亡率最高的一种恶性肿瘤,多数患者初次诊断即为晚期。现有的治疗方案是肿瘤细胞减灭术并辅以铂类为基础的联合化疗,但容易出现耐药和复发,因此迫切需要开发新的治疗方案。铁死亡是近年来发现的一种调节性细胞死亡形式,是铁依赖性的、非凋亡形式的细胞死亡过程。现有多项研究表明,铁死亡与卵巢癌相关。本文综述了铁死亡在卵巢癌中的发生机制、铁死亡诱导剂与抑制剂对卵巢癌的作用以及铁死亡在铂耐药卵巢癌中的应用,以期为后续的卵巢癌治疗提供新的思路和方向。Ovarian cancer is a malignant tumor with the highest rate of mortality in the female reproductive system globally, however, and most patients are diagnosed at an advanced stage at first. The current treatment strategy of tumor cytoreduction supplemented with platinum-based combination chemotherapy is prone to drug resistance and relapse, necessitating the urgent need to develop new treatment options. Ferroptosis is a form of regulated cell death (RCD) discovered in recent years, and it is an iron-dependent, non-apoptotic form of cell death process. Several existing studies have shown that ferroptosis is associated with ovarian cancer. Therefore, this article reviews the mechanism of ferroptosis in ovarian cancer, the role of inducers and inhibitors of ferroptosis in ovarian cancer, and the application of ferroptosis in platinum-resistant ovarian cancer, with a view to providing new ideas and directions for subsequent ovarian cancer treatment.展开更多
右心功能的评估在心血管疾病的诊断、治疗和预后判断中具有重要意义。近年来,随着影像学技术的不断发展,尤其是二维斑点追踪(2D Speckle Tracking Imaging, 2D-STE)技术的应用,右心功能的评价方法得到了显著的提升。二维斑点追踪通过分...右心功能的评估在心血管疾病的诊断、治疗和预后判断中具有重要意义。近年来,随着影像学技术的不断发展,尤其是二维斑点追踪(2D Speckle Tracking Imaging, 2D-STE)技术的应用,右心功能的评价方法得到了显著的提升。二维斑点追踪通过分析心脏超声图像中的斑点运动,能够提供更为精确的右心功能评估,尤其是在传统方法难以准确评估的区域,如右心房、右心室的扭转、应变和应变率等方面。本文旨在综述二维斑点追踪技术在右心功能评估中的最新研究进展,探讨其在右心室和右心房功能、右心舒张功能以及与右心功能相关的临床应用中的潜力。文章还将讨论二维斑点追踪技术的局限性和未来发展方向,期望为临床实践提供参考,并促进这一领域的进一步研究。The assessment of right ventricular function plays a significant role in the diagnosis, treatment, and prognosis of cardiovascular diseases. In recent years, with the continuous development of imaging techniques, especially the application of two-dimensional speckle tracking (2D Speckle Tracking Imaging, 2D-STE) technology, the methods for evaluating right ventricular function have been significantly improved. Two-dimensional speckle tracking analyzes the motion of speckles in cardiac ultrasound images, providing a more accurate assessment of right ventricular function, particularly in areas where traditional methods struggle to provide accurate evaluations, such as right atrial and right ventricular torsion, strain, and strain rate. This article aims to review the latest research progress in the application of two-dimensional speckle tracking technology in the assessment of right ventricular function, exploring its potential in the evaluation of right ventricular and right atrial function, right ventricular diastolic function, and its clinical applications related to right ventricular function. The article will also discuss the limitations of two-dimensional speckle tracking technology and its future development directions, with the hope of providing a reference for clinical practice and promoting further research in this field.展开更多
胃食管反流病(Gastroesophageal Reflux Disease, GERD)是一种常见的消化系统疾病,其治疗包括药物和内镜治疗。质子泵抑制剂(Proton Pump Inhibitors, PPIs)仍是主要药物,钾–氢泵抑制剂(Potassium-Competitive Acid Blockers, P-CABs)...胃食管反流病(Gastroesophageal Reflux Disease, GERD)是一种常见的消化系统疾病,其治疗包括药物和内镜治疗。质子泵抑制剂(Proton Pump Inhibitors, PPIs)仍是主要药物,钾–氢泵抑制剂(Potassium-Competitive Acid Blockers, P-CABs)等新型药物逐步应用。内镜治疗技术不断发展,为药物难治性GERD提供了新选择。本文综述GERD的药物及内镜治疗的现状,分析其疗效、局限性,并展望未来发展方向,以期为临床治疗提供参考。Gastroesophageal Reflux Disease (GERD) is a common digestive disorder, with treatment strategies including pharmacological and endoscopic therapies. Proton Pump Inhibitors (PPIs) are still the main drugs, while novel agents such as Potassium-Competitive Acid Blockers (P-CABs) are increasingly utilized. Advances in endoscopic techniques offer new therapeutic options for drug-refractory GERD. This review summarizes the current status of pharmacological and endoscopic treatments for GERD, discusses their efficacy and limitations, and explores future perspectives to provide a reference for clinical treatment.展开更多
目的:研究剖宫产术后腹壁子宫内膜异位症(AWE)的临床特征,以了解其相关特点。方法:对滨州医学院附属医院在2018年1月至2024年5月期间收治的134例经组织病理证实为剖宫产术后腹壁子宫内膜异位症患者的临床资料进行回顾性分析。根据腹壁...目的:研究剖宫产术后腹壁子宫内膜异位症(AWE)的临床特征,以了解其相关特点。方法:对滨州医学院附属医院在2018年1月至2024年5月期间收治的134例经组织病理证实为剖宫产术后腹壁子宫内膜异位症患者的临床资料进行回顾性分析。根据腹壁子宫内膜异位症病灶的侵袭深度及范围,将其分为皮下脂肪型、鞘膜型和腹膜型三种类型。按照内异症病灶数量分为单发型、多发型。比较腹壁子宫内膜异位症各个分型之间的临床特点及差异。结果:根据术中探查内异症病灶数分型,单发型122例(91%),多发型12例(9%)。与单发型相比,多发型AWE的手术时间长(P P P = 0.035),手术时间更长(P P P P P P Objective: To investigate the clinical characteristics of abdominal wall endometriosis (AWE) after cesarean section in order to understand its related characteristics. Methods: The clinical data of 134 patients with abdominal wall endometriosis confirmed by histopathology admitted to the Affiliated Hospital of Binzhou Medical University from January 2018 to May 2024 were retrospectively analyzed. According to the invasion depth and scope of abdominal endometriosis, the lesions were classified into subcutaneous lipomatosis, vaginalis, and peritoneum. Based on the number of endometriosis lesions, it can be divided into single types and multiple types. To compare the clinical features and differences among different types of abdominal endometriosis. Results: According to the number of intraoperative investigations, there were 122 cases (91%) of single type and 12 cases (9%) of multiple type. Compared with single-style AWE, multi-style AWE had longer operation time (P P P = 0.035), longer operation time (P P P P P P < 0.01).展开更多
文摘本文主要研究了页岩气分簇式射孔技术及其复杂故障控制方法。首先概述了页岩气开发现状与分簇式射孔技术应用现状。接着详细分析了页岩气分簇式射孔复杂故障类型及成因,探讨了技术、操作、设备与维护等方面导致故障的因素。根据复杂故障原因探讨了故障预防策略、故障诊断技术以及故障处理与应对措施,提出设备优化射孔方案设计、实时监测与预警系统等预防策略,以及针对不同故障的处理方法。之后阐述了复杂故障控制方法的实施流程、实施过程中的关键问题与解决方案。最后总结了研究成果,并对未来研究方向进行了展望。This paper mainly studies the shale gas cluster perforation technology and its complex fault control methods. Firstly, it outlines the current status of shale gas development and the application status of cluster perforation technology. Then, it analyzes in detail the types and causes of complex faults in shale gas cluster perforation, and discusses the factors leading to faults in terms of technology, operation, equipment, and maintenance. Based on the causes of complex faults, strategies for fault prevention, fault diagnosis technology, and fault handling and response measures are discussed. Proposals include equipment optimization perforation scheme design, real-time monitoring and early warning systems, as well as handling methods for different faults. Subsequently, the implementation process of the complex fault control method, key issues in the implementation process, and solutions are described. Finally, the research results are summarized, and the future research directions are prospected.
文摘背景:血管阻力(VR)指的是血液在流经血管过程中所遇到的阻力。这是一种在正常血液循环和心脏功能中发挥关键作用的生理现象。然而,异常的血管阻力是多种循环系统疾病和心血管病理状态的基础。尽管近年来对血管阻力展开了广泛研究,但迄今为止尚未有相关的文献计量分析。本研究旨在阐明血管阻力研究的发展趋势和新兴焦点,为未来的研究以及基于证据的决策提供指导。方法:所有相关文献均从Web of Science核心合集(WoSCC)数据库中获取。采用HistCite、CiteSpace和VOSviewer对文献进行计量分析和可视化处理。结果:本研究的主要学科领域为“生物学与医学”。共纳入6645篇与“血管阻力”相关的英文文献,年度发表数量呈现稳定趋势。美国在发表文献数量和引用量上均位居第一。产出最多的机构、期刊和作者分别为Mayo Clinic、Pulmonary Circulation和Marc Humbert;而引用量最高的期刊和作者则分别为International Journal of Cardiology和Simonneau,Gerald。伦敦帝国学院在机构间的合作最为广泛。在聚类分析中,“心力衰竭”(聚类0#)为最大的聚类。此外,“肺动脉高压”、“血压”和“血管阻力”为主要关键词,而“社会”和“性别差异”则是近年来出现的最新突现关键词。结论:肺动脉高压可能成为血管阻力领域的新兴热点,这在一定程度上与2019冠状病毒病(COVID-19)与肺动脉高压之间的关联有关。近期在慢性血栓栓塞性肺动脉高压(CTEPH)研究中的进展,有助于深入理解肺部疾病的发病机制和治疗策略。此外,血管阻力监测技术在心血管疾病的诊断和管理中具有重要的临床意义。Background: Vascular Resistance (VR) refers to the resistance encountered by blood flow as it moves through the blood vessels. It is a physiological phenomenon that plays a vital role in normal blood circulation and heart function. Nonetheless, aberrant vascular resistance underlies various circulatory disorders and cardiovascular pathologies. Despite extensive investigations of VR in recent years, no bibliometric analysis has been conducted thus far. The objective of this is to elucidate the evolutionary trends and emerging focal points within VR research while offering guidance for future investigations and evidence-based decision-making. Methods: All the relevant literature was obtained from the Web of Science Core Collection (WoSCC) database. HistCite, CiteSpace, and VOSviewer were employed to perform bibliometric analysis and visualization. Results: “Biology and Medicine” is the main research categories in this research. A total of 6645 English documents related to “Vascular Resistance” were included. The number of annual publications shows a stable trend. The United States is the country with the largest publications and the largest citations. The most productive institution, journal, and author are Mayo Clinic, Pulmonary Circulation, Marc Humbert, respectively. The most highly cited journal and author are International Journal of Cardiology, and Simonneau, Gerald. Imperial College London had the most extensive collaboration among the institutions. In clustering analysis, “heart failure” (cluster 0#) is the largest cluster. Moreover, “pulmonary hypertension”, “blood pressure”, and “vascular resistance” are the primary keywords. “Society” and “sex difference” are the newest burst keywords in recent years. Conclusion: Pulmonary hypertension may become an emerging hotspot in the field of VR, partly because of the link between Corona Virus Disease 2019 and pulmonary hypertension. Recent advances in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) research help understand the pathogenesis and treatment of lung diseases. In addition, VR monitoring technique has important clinical significance for the diagnosis and management of cardiovascular diseases.
文摘多囊卵巢综合征(polycystic ovary syndrome, PCOS)和桥本甲状腺炎(Hashimoto’s thyroiditis, HT)均为育龄期女性常见的内分泌代谢紊乱性疾病。临床观察发现,PCOS与HT具有相似的临床表现。近年来,越来越多的研究证实,PCOS女性中HT的发生率明显高于一般人群,二者共病将进一步加重生殖障碍和代谢紊乱。提示这两种疾病之间可能存在某种关联,但内在的病理生理机制尚不清楚。探讨PCOS与HT之间的相互关系对PCOS的临床管理具有重要意义。PCOS and HT are common endocrine and metabolic disorders in women of childbearing age. Clinical observations show that PCOS and HT have similar clinical manifestations. In recent years, more and more studies have confirmed that the incidence of HT in women with PCOS is significantly higher than that in the general population, and the comorbidity of the two further aggravates reproductive disorders and metabolic disorders. It is suggested that there may be some correlation between the two diseases, but the underlying pathological and physiological mechanism is still unclear. It is of great significance to explore the interrelationship between PCOS and HT for the clinical management of PCOS.
文摘对于中医流派传承模式的不断探索,是中医流派生存与发展的必经之路。本文以介绍谢氏正骨流派在自身发展中逐步形成的传承模式,探讨传承模式对中医流派发展的影响。基于以下几点:首先需要强化流派“导师”团队建设,其次需要优化流派内部人才培养模式,最后需要完善流派传承管理制度。The continuous exploration of the inheritance mode of traditional Chinese medicine schools is a necessary path for the survival and development of traditional Chinese medicine schools. This article introduces the inheritance model gradually formed by Xie’s Orthopedic School in its own development, and explores the impact of inheritance models on the development of traditional Chinese medicine schools. Based on the following points: Firstly, it is necessary to strengthen the construction of the “mentor” team of the school. Secondly, it is necessary to optimize the internal talent training mode of the school. Finally, it is necessary to improve the school inheritance management system.
文摘卵巢癌是全球女性生殖系统中死亡率最高的一种恶性肿瘤,多数患者初次诊断即为晚期。现有的治疗方案是肿瘤细胞减灭术并辅以铂类为基础的联合化疗,但容易出现耐药和复发,因此迫切需要开发新的治疗方案。铁死亡是近年来发现的一种调节性细胞死亡形式,是铁依赖性的、非凋亡形式的细胞死亡过程。现有多项研究表明,铁死亡与卵巢癌相关。本文综述了铁死亡在卵巢癌中的发生机制、铁死亡诱导剂与抑制剂对卵巢癌的作用以及铁死亡在铂耐药卵巢癌中的应用,以期为后续的卵巢癌治疗提供新的思路和方向。Ovarian cancer is a malignant tumor with the highest rate of mortality in the female reproductive system globally, however, and most patients are diagnosed at an advanced stage at first. The current treatment strategy of tumor cytoreduction supplemented with platinum-based combination chemotherapy is prone to drug resistance and relapse, necessitating the urgent need to develop new treatment options. Ferroptosis is a form of regulated cell death (RCD) discovered in recent years, and it is an iron-dependent, non-apoptotic form of cell death process. Several existing studies have shown that ferroptosis is associated with ovarian cancer. Therefore, this article reviews the mechanism of ferroptosis in ovarian cancer, the role of inducers and inhibitors of ferroptosis in ovarian cancer, and the application of ferroptosis in platinum-resistant ovarian cancer, with a view to providing new ideas and directions for subsequent ovarian cancer treatment.
文摘右心功能的评估在心血管疾病的诊断、治疗和预后判断中具有重要意义。近年来,随着影像学技术的不断发展,尤其是二维斑点追踪(2D Speckle Tracking Imaging, 2D-STE)技术的应用,右心功能的评价方法得到了显著的提升。二维斑点追踪通过分析心脏超声图像中的斑点运动,能够提供更为精确的右心功能评估,尤其是在传统方法难以准确评估的区域,如右心房、右心室的扭转、应变和应变率等方面。本文旨在综述二维斑点追踪技术在右心功能评估中的最新研究进展,探讨其在右心室和右心房功能、右心舒张功能以及与右心功能相关的临床应用中的潜力。文章还将讨论二维斑点追踪技术的局限性和未来发展方向,期望为临床实践提供参考,并促进这一领域的进一步研究。The assessment of right ventricular function plays a significant role in the diagnosis, treatment, and prognosis of cardiovascular diseases. In recent years, with the continuous development of imaging techniques, especially the application of two-dimensional speckle tracking (2D Speckle Tracking Imaging, 2D-STE) technology, the methods for evaluating right ventricular function have been significantly improved. Two-dimensional speckle tracking analyzes the motion of speckles in cardiac ultrasound images, providing a more accurate assessment of right ventricular function, particularly in areas where traditional methods struggle to provide accurate evaluations, such as right atrial and right ventricular torsion, strain, and strain rate. This article aims to review the latest research progress in the application of two-dimensional speckle tracking technology in the assessment of right ventricular function, exploring its potential in the evaluation of right ventricular and right atrial function, right ventricular diastolic function, and its clinical applications related to right ventricular function. The article will also discuss the limitations of two-dimensional speckle tracking technology and its future development directions, with the hope of providing a reference for clinical practice and promoting further research in this field.
文摘胃食管反流病(Gastroesophageal Reflux Disease, GERD)是一种常见的消化系统疾病,其治疗包括药物和内镜治疗。质子泵抑制剂(Proton Pump Inhibitors, PPIs)仍是主要药物,钾–氢泵抑制剂(Potassium-Competitive Acid Blockers, P-CABs)等新型药物逐步应用。内镜治疗技术不断发展,为药物难治性GERD提供了新选择。本文综述GERD的药物及内镜治疗的现状,分析其疗效、局限性,并展望未来发展方向,以期为临床治疗提供参考。Gastroesophageal Reflux Disease (GERD) is a common digestive disorder, with treatment strategies including pharmacological and endoscopic therapies. Proton Pump Inhibitors (PPIs) are still the main drugs, while novel agents such as Potassium-Competitive Acid Blockers (P-CABs) are increasingly utilized. Advances in endoscopic techniques offer new therapeutic options for drug-refractory GERD. This review summarizes the current status of pharmacological and endoscopic treatments for GERD, discusses their efficacy and limitations, and explores future perspectives to provide a reference for clinical treatment.
文摘目的:研究剖宫产术后腹壁子宫内膜异位症(AWE)的临床特征,以了解其相关特点。方法:对滨州医学院附属医院在2018年1月至2024年5月期间收治的134例经组织病理证实为剖宫产术后腹壁子宫内膜异位症患者的临床资料进行回顾性分析。根据腹壁子宫内膜异位症病灶的侵袭深度及范围,将其分为皮下脂肪型、鞘膜型和腹膜型三种类型。按照内异症病灶数量分为单发型、多发型。比较腹壁子宫内膜异位症各个分型之间的临床特点及差异。结果:根据术中探查内异症病灶数分型,单发型122例(91%),多发型12例(9%)。与单发型相比,多发型AWE的手术时间长(P P P = 0.035),手术时间更长(P P P P P P Objective: To investigate the clinical characteristics of abdominal wall endometriosis (AWE) after cesarean section in order to understand its related characteristics. Methods: The clinical data of 134 patients with abdominal wall endometriosis confirmed by histopathology admitted to the Affiliated Hospital of Binzhou Medical University from January 2018 to May 2024 were retrospectively analyzed. According to the invasion depth and scope of abdominal endometriosis, the lesions were classified into subcutaneous lipomatosis, vaginalis, and peritoneum. Based on the number of endometriosis lesions, it can be divided into single types and multiple types. To compare the clinical features and differences among different types of abdominal endometriosis. Results: According to the number of intraoperative investigations, there were 122 cases (91%) of single type and 12 cases (9%) of multiple type. Compared with single-style AWE, multi-style AWE had longer operation time (P P P = 0.035), longer operation time (P P P P P P < 0.01).
