Zaleplon was synthesized through condensation of N-(3-acetylphenyl)acetamide(6) with dimethylformamide dimethylacetal(2), alkylation with ethyl bromide and then cyclization with 3-aminopyrazole-4-carbonitrile(4) at 50...Zaleplon was synthesized through condensation of N-(3-acetylphenyl)acetamide(6) with dimethylformamide dimethylacetal(2), alkylation with ethyl bromide and then cyclization with 3-aminopyrazole-4-carbonitrile(4) at 50℃ in acetic acid and water. 2 and 4 were prepared from DMF and malononitrile respectively. The structure of Zaleplon was identified by IR, UV, +1HNMR, MS and elemental analysis.展开更多
文摘Zaleplon was synthesized through condensation of N-(3-acetylphenyl)acetamide(6) with dimethylformamide dimethylacetal(2), alkylation with ethyl bromide and then cyclization with 3-aminopyrazole-4-carbonitrile(4) at 50℃ in acetic acid and water. 2 and 4 were prepared from DMF and malononitrile respectively. The structure of Zaleplon was identified by IR, UV, +1HNMR, MS and elemental analysis.
