Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-...Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-lesterolemia,physicians pay less attention to the morbidity,causes and consequences of hypocholesterolemia in clinical practice.In fact,hypocholesterolemia is a common dislipidemia,and mainly results from secondary factors.The causes of primary hypocholesterolemia are some disorders owing to genetic mutation in the pathway of cholesterol absorption,biosynthesis or metabolism,including abetalipoproteinemia,hypobetalipoproteinemia,Tangier disease,chylomicron retention disease and inherited disorders of cholesterol biosynthesis.The causes of secondary hypocholesterolemia comprise anemia,hyperthyroidism,malignancy,live disease,critical illness,serious stress,malabsorption or malnutrition,acute or chronic infection,chronic inflammation,and use of some drugs.In addition,what’s more important is that hypocholesterolemia can result in some adverse events,such as increased mortality,intracerebral hemorrhage,cancer,infection,adrenal failure,suicide and mental disorder.Therefore,with the practice of intensive lipid-lowering treatment and the tendency to the increased indications of statins,it’s high time that physicians attached more importance to hypocholesterolemia.展开更多
文摘Hypocholesterolemia is characterized by serum total cholesterol that is lower than the 5th percentile for age and sex,or the cut-off value which predicts the adverse prognosis by epidemiological study.Unlike hypercho-lesterolemia,physicians pay less attention to the morbidity,causes and consequences of hypocholesterolemia in clinical practice.In fact,hypocholesterolemia is a common dislipidemia,and mainly results from secondary factors.The causes of primary hypocholesterolemia are some disorders owing to genetic mutation in the pathway of cholesterol absorption,biosynthesis or metabolism,including abetalipoproteinemia,hypobetalipoproteinemia,Tangier disease,chylomicron retention disease and inherited disorders of cholesterol biosynthesis.The causes of secondary hypocholesterolemia comprise anemia,hyperthyroidism,malignancy,live disease,critical illness,serious stress,malabsorption or malnutrition,acute or chronic infection,chronic inflammation,and use of some drugs.In addition,what’s more important is that hypocholesterolemia can result in some adverse events,such as increased mortality,intracerebral hemorrhage,cancer,infection,adrenal failure,suicide and mental disorder.Therefore,with the practice of intensive lipid-lowering treatment and the tendency to the increased indications of statins,it’s high time that physicians attached more importance to hypocholesterolemia.
文摘对于急性心肌梗死（acute myocardial infarction,AMI）的救治,＂时间就是心肌,时间就是生命＂已是公认的救治理念。在发病早期及时开通梗死血管,有效恢复心肌再灌注,是降低AMI患者病死率、改善预后的关键。目前,指南对AMI再灌注治疗时间提出了具体要求,主要包括入院至球囊扩张时间（door to balloon,D2B）、
