芹菜甲素(1)是芹菜挥发油的主要成份,同时还广泛存在于伞形科和菊科的其他植物中。它具有很强的抗惊能力,能解除鼠、兔和 Mes、MST、MAS 等动物模型由各种原因引起的惊厥反应。实验表明,芹菜甲素是一类不含 N 原子的新型广谱抗惊化合物...芹菜甲素(1)是芹菜挥发油的主要成份,同时还广泛存在于伞形科和菊科的其他植物中。它具有很强的抗惊能力,能解除鼠、兔和 Mes、MST、MAS 等动物模型由各种原因引起的惊厥反应。实验表明,芹菜甲素是一类不含 N 原子的新型广谱抗惊化合物。合成的(±)-芹菜甲素似乎表现出比天然芹菜甲素更强的药理活性。另外,芹菜甲素具有天然香蕉芬芳气味,可应用于食品工业。展开更多
The enantioselective total synthesis of 12 carboxyeudesma 3,11(13) diene(1) was achieved starting from(-) dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group...The enantioselective total synthesis of 12 carboxyeudesma 3,11(13) diene(1) was achieved starting from(-) dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C 12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.展开更多
文摘芹菜甲素(1)是芹菜挥发油的主要成份,同时还广泛存在于伞形科和菊科的其他植物中。它具有很强的抗惊能力,能解除鼠、兔和 Mes、MST、MAS 等动物模型由各种原因引起的惊厥反应。实验表明,芹菜甲素是一类不含 N 原子的新型广谱抗惊化合物。合成的(±)-芹菜甲素似乎表现出比天然芹菜甲素更强的药理活性。另外,芹菜甲素具有天然香蕉芬芳气味,可应用于食品工业。
文摘The enantioselective total synthesis of 12 carboxyeudesma 3,11(13) diene(1) was achieved starting from(-) dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C 12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.
