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补气补血药促造血作用现代医学研究进展
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作者 段爽爽 李焱 +2 位作者 韩净净 韩锦煊 辛春雷 《医学诊断》 2025年第1期123-133,共11页
现代医学研究发现,传统中药在促进造血方面取得了令人瞩目的进展,多种中药可通过多种复杂的机制发挥其促造血作用。在传统医学中,造血过程被认为与气血的生成相关。研究表明许多中药及其活性成分可通过保护及促进造血干细胞增殖及分化... 现代医学研究发现,传统中药在促进造血方面取得了令人瞩目的进展,多种中药可通过多种复杂的机制发挥其促造血作用。在传统医学中,造血过程被认为与气血的生成相关。研究表明许多中药及其活性成分可通过保护及促进造血干细胞增殖及分化、调节造血微环境、调控造血生长因子、激活造血相关信号通路等方式发挥促造血作用,许多中药有望成为血液系统疾病治疗的良好制剂。文章综述了中药促造血机制,以及近年来研究发现具有促造血作用的补气药及补血药。中药活性成分的复杂性和多样性使得其机制的研究变得困难,中药的标准化和质量控制问题亟需解决。随着对中药活性成分的深入研究,越来越多的中药制剂被应用于临床造血功能障碍的治疗。总的来说,传统中药及其活性成分在造血过程中的研究正在不断深入,未来将展现出广阔的发展前景。Modern medical research has found that traditional Chinese medicine has made remarkable progress in promoting hematopoiesis, and a variety of traditional Chinese medicines can exert their hematopoietic effects through a variety of complex mechanisms. In traditional medicine, the hematopoietic process is thought to be associated with the production of Qi and blood. Studies have shown that many traditional Chinese medicines and their active ingredients can play a role in promoting hematopoiesis by protecting and promoting the proliferation and differentiation of hematopoietic stem cells, regulating the hematopoietic microenvironment, regulating hematopoietic growth factors, and activating hematopoietic-related signaling pathways, and many TCMs are expected to become good preparations for the treatment of hematopoietic diseases. This article reviews the hematopoietic mechanism of traditional Chinese medicine, as well as the Qi tonic drugs and blood tonic drugs that have been found to promote hematopoiesis in recent years. The complexity and diversity of active ingredients in traditional Chinese medicine make it difficult to study their mechanisms, and the standardization and quality control of traditional Chinese medicine needs to be solved urgently. With in-depth research on the active ingredients of traditional Chinese medicine, more and more traditional Chinese medicine preparations are used in the treatment of clinical hematopoietic dysfunction. In general, the research on traditional Chinese medicine and its active ingredients in the hematopoietic process is deepening, and it will show broad development prospects in the future. 展开更多
关键词 中药 造血系统 补气药 补血药 信号通路
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皮肤损害为首发症状的淋巴瘤1例
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作者 段爽爽 韩净净 辛春雷 《临床个性化医学》 2024年第4期1483-1489,共7页
目的:通过1例以皮肤损害为首发症状的结外NK/T细胞淋巴瘤的病例,探讨该病例诊治线索及治疗时机。方法:回顾性分析我院1例皮肤损害为首发症状的结外NK/T细胞淋巴瘤临床表现、诊治思路、治疗结局,并进行相关文献复习。结果:该例患者因肿... 目的:通过1例以皮肤损害为首发症状的结外NK/T细胞淋巴瘤的病例,探讨该病例诊治线索及治疗时机。方法:回顾性分析我院1例皮肤损害为首发症状的结外NK/T细胞淋巴瘤临床表现、诊治思路、治疗结局,并进行相关文献复习。结果:该例患者因肿瘤转移合并感染,最终自动出院。结论:以皮肤损害为首发症状的结外NK/T细胞淋巴瘤患者的早期诊断及治疗十分重要。Objective: A case of extranodal NK/T cell lymphoma with skin lesion as the first symptom was studied to explore the clues of diagnosis and treatment and the opportunity of treatment. Methods: The clinical manifestations, diagnosis and treatment ideas, and treatment outcome of 1 case of extranodal NK/T cell lymphoma with skin lesion as the first symptom in our hospital were retrospectively analyzed, and the relevant literature was reviewed. Results: The patient was discharged automatically due to tumor metastasis and infection. Conclusions: Early diagnosis and treatment of extranodal NK/T cell lymphoma with skin lesion as the first symptom are very important. 展开更多
关键词 NK/T细胞淋巴瘤 皮肤损害 治疗
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造血干细胞衰老分子机制研究进展 被引量:1
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作者 韩净净 段爽爽 辛春雷 《社区医学杂志》 CAS 2024年第3期101-106,共6页
造血干细胞可以满足机体对各类血细胞的需要,随着年龄的增长,造血干细胞逐渐衰老,其功能减退、数量变化,生物体衰老起源于干细胞衰老,随着人口老龄化,衰老相关疾病日益受到关注,本研究通过细胞内在与外在因素2个方面讨论造血干细胞分子... 造血干细胞可以满足机体对各类血细胞的需要,随着年龄的增长,造血干细胞逐渐衰老,其功能减退、数量变化,生物体衰老起源于干细胞衰老,随着人口老龄化,衰老相关疾病日益受到关注,本研究通过细胞内在与外在因素2个方面讨论造血干细胞分子衰老机制。以“造血干细胞”“衰老”为关键词,检索2018-01-01-2023-07-31中国知网及PubMed相关文献。纳入标准:造血干细胞衰老相关通路的研究;造血干细胞衰老和DNA损伤的研究;造血干细胞衰老和代谢的研究;造血干细胞衰老和表观遗传学的研究;造血干细胞衰老和环境的研究。排除标准:年份较远、质量较差的文献。最终纳入分析文献52篇。结果表明,造血干细胞衰老的分子机制涉及细胞内外因素,其中DNA损伤、代谢、表观遗传学、环境等因素参与造血干细胞衰老过程。进一步研究造血干细胞衰老相关分子机制,有望发现更多有效的延缓甚至逆转造血干细胞衰老过程的新靶点。 展开更多
关键词 造血干细胞 衰老 DNA损伤 表观遗传学
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