辅助基因调控(agr)群体感应系统通过调控毒力因子及生物被膜形成等影响金黄色葡萄球菌毒力的表达。agr的信号传导主要依赖于自诱导信号肽(AIP)与AgrC结合后激活AgrA,而后直接由AgrA或转录后调节因子RNAIII作用于下游靶基因调控金黄色葡...辅助基因调控(agr)群体感应系统通过调控毒力因子及生物被膜形成等影响金黄色葡萄球菌毒力的表达。agr的信号传导主要依赖于自诱导信号肽(AIP)与AgrC结合后激活AgrA,而后直接由AgrA或转录后调节因子RNAIII作用于下游靶基因调控金黄色葡萄球菌的毒力因子。本综述主要讲述了AIP与AgrC结合以及AgrA作用于下游靶基因的机制。讨论了agr阴性突变菌株感染对临床患者的影响,还讨论了多种毒力调控基因与agr共同作用调节金葡菌毒力的复杂网络。Accessory gene regulator (agr) quorum sensing network affects the expression of Staphylococcus aureus virulence by regulating virulence factors and biofilm formation. The signal transduction of agr mainly depends on the activation of AgrA after the binding of AIP with AgrC, and then the direct action of AgrA or the post-transcriptional regulatory factor RNAIII on the downstream target gene to regulate the virulence factors of Staphylococcus aureus. This review mainly describes the mechanism of AIP binding to AgrC and AgrA acting on downstream target genes. The effects of agr negative mutant strains on clinical patients were discussed, and the complex network of virulence regulation genes and agr regulating Staphylococcus aureus was discussed.展开更多
文摘辅助基因调控(agr)群体感应系统通过调控毒力因子及生物被膜形成等影响金黄色葡萄球菌毒力的表达。agr的信号传导主要依赖于自诱导信号肽(AIP)与AgrC结合后激活AgrA,而后直接由AgrA或转录后调节因子RNAIII作用于下游靶基因调控金黄色葡萄球菌的毒力因子。本综述主要讲述了AIP与AgrC结合以及AgrA作用于下游靶基因的机制。讨论了agr阴性突变菌株感染对临床患者的影响,还讨论了多种毒力调控基因与agr共同作用调节金葡菌毒力的复杂网络。Accessory gene regulator (agr) quorum sensing network affects the expression of Staphylococcus aureus virulence by regulating virulence factors and biofilm formation. The signal transduction of agr mainly depends on the activation of AgrA after the binding of AIP with AgrC, and then the direct action of AgrA or the post-transcriptional regulatory factor RNAIII on the downstream target gene to regulate the virulence factors of Staphylococcus aureus. This review mainly describes the mechanism of AIP binding to AgrC and AgrA acting on downstream target genes. The effects of agr negative mutant strains on clinical patients were discussed, and the complex network of virulence regulation genes and agr regulating Staphylococcus aureus was discussed.
