目的:该研究旨在剖析静脉溶栓的急性缺血性卒中(acute ischemic stroke, AIS)患者体内血清尿酸(serum uric acid, SUA)水平和出血性转化(hemorrhagic transformation, HT)之间的相互关系。方法:对2020~2024年在院接受静脉溶栓治疗的急...目的:该研究旨在剖析静脉溶栓的急性缺血性卒中(acute ischemic stroke, AIS)患者体内血清尿酸(serum uric acid, SUA)水平和出血性转化(hemorrhagic transformation, HT)之间的相互关系。方法:对2020~2024年在院接受静脉溶栓治疗的急性大脑前循环缺血患者进行回顾性研究,在患者入院7天内通过颅脑CT检测出血性转化情况。比较HT组和非HT组之间以及根据欧洲合作急性卒中研究分类III (ECASS III)分类的不同类型HT组之间的基线资料、临床和实验室数据。结果:该研究共纳入701例AIS患者,其中102例发生HT,599例未发生HT。与非HT组的患者相比,HT组患者的尿酸(uric acid, UA)水平显著降低(251.85 ± 92.13 vs 307.73 ± 76.66, p Objective: To explore the relationship between SUA and HT after intravenous thrombolysis in patients with acute AIS. Methods: A retrospective analysis was performed on patients with anterior circulation AIS who received intravenous thrombolysis in the hospital from 2020 to 2024. HT was detected by brain CT or MRI within 7 days of admission. We compare baseline demographic, clinical, and laboratory data between the HT group and the non-HT group and between the different types of HT groups recorded according to the ECASS III. Results: 701 AIS patients who underwent intravenous rt-PA thrombolysis within 4.5 h after onset of AIS were divided into HT group (102) and Non-HT group (599). Compared with patients without HT, the UA level of HT patients was significantly reduced (251.85 ± 92.13 vs 307.73 ± 76.66, p < 0.01), but there was no significant difference between UA and HT types (p = 0.64). After adjusting for confounding factors, compared with the first quartile, the risk of HT in the fourth quartile was significantly reduced (OR 0.187, 95% CI 0.067~ 0.526, p = 0.001). Conclusion: Low levels of SUA may increase the risk of HT after intravenous thrombolysis.展开更多
慢性肾脏病(chronic kidney disease,CKD)发病率在我国呈逐年上升趋势,低蛋白饮食(low protein diet,LPD)是延缓CKD病情发展有效的食疗方法之一。本文就近年来日益受到广泛关注的低蛋白调整大米的研究方法进行了综述和展望,分析了包括...慢性肾脏病(chronic kidney disease,CKD)发病率在我国呈逐年上升趋势,低蛋白饮食(low protein diet,LPD)是延缓CKD病情发展有效的食疗方法之一。本文就近年来日益受到广泛关注的低蛋白调整大米的研究方法进行了综述和展望,分析了包括育种栽培、物理方法、化学方法、生物技术降解等方法的优势与不足。其中利用生物技术降解整粒大米蛋白,能够在保持大米原有完整性和口感的同时大幅度降低其蛋白含量,产品更适合肾病患者长期食用。我国约2/3居民以大米为主食,肾病患者人数越来越多,而国内相关的低蛋白产品还相对较少,无法大众化,故从改善患者主食方面研制出符合患者饮食习惯的低蛋白大米的市场前景非常可观。展开更多
文摘目的:该研究旨在剖析静脉溶栓的急性缺血性卒中(acute ischemic stroke, AIS)患者体内血清尿酸(serum uric acid, SUA)水平和出血性转化(hemorrhagic transformation, HT)之间的相互关系。方法:对2020~2024年在院接受静脉溶栓治疗的急性大脑前循环缺血患者进行回顾性研究,在患者入院7天内通过颅脑CT检测出血性转化情况。比较HT组和非HT组之间以及根据欧洲合作急性卒中研究分类III (ECASS III)分类的不同类型HT组之间的基线资料、临床和实验室数据。结果:该研究共纳入701例AIS患者,其中102例发生HT,599例未发生HT。与非HT组的患者相比,HT组患者的尿酸(uric acid, UA)水平显著降低(251.85 ± 92.13 vs 307.73 ± 76.66, p Objective: To explore the relationship between SUA and HT after intravenous thrombolysis in patients with acute AIS. Methods: A retrospective analysis was performed on patients with anterior circulation AIS who received intravenous thrombolysis in the hospital from 2020 to 2024. HT was detected by brain CT or MRI within 7 days of admission. We compare baseline demographic, clinical, and laboratory data between the HT group and the non-HT group and between the different types of HT groups recorded according to the ECASS III. Results: 701 AIS patients who underwent intravenous rt-PA thrombolysis within 4.5 h after onset of AIS were divided into HT group (102) and Non-HT group (599). Compared with patients without HT, the UA level of HT patients was significantly reduced (251.85 ± 92.13 vs 307.73 ± 76.66, p < 0.01), but there was no significant difference between UA and HT types (p = 0.64). After adjusting for confounding factors, compared with the first quartile, the risk of HT in the fourth quartile was significantly reduced (OR 0.187, 95% CI 0.067~ 0.526, p = 0.001). Conclusion: Low levels of SUA may increase the risk of HT after intravenous thrombolysis.
文摘慢性肾脏病(chronic kidney disease,CKD)发病率在我国呈逐年上升趋势,低蛋白饮食(low protein diet,LPD)是延缓CKD病情发展有效的食疗方法之一。本文就近年来日益受到广泛关注的低蛋白调整大米的研究方法进行了综述和展望,分析了包括育种栽培、物理方法、化学方法、生物技术降解等方法的优势与不足。其中利用生物技术降解整粒大米蛋白,能够在保持大米原有完整性和口感的同时大幅度降低其蛋白含量,产品更适合肾病患者长期食用。我国约2/3居民以大米为主食,肾病患者人数越来越多,而国内相关的低蛋白产品还相对较少,无法大众化,故从改善患者主食方面研制出符合患者饮食习惯的低蛋白大米的市场前景非常可观。
