The self-assembly of diblock copolymers confined around one square-shaped particle is studied systematically within two-dimensional self-consistent field theory（SCFT）.In this model,we assume that the thin block copo...The self-assembly of diblock copolymers confined around one square-shaped particle is studied systematically within two-dimensional self-consistent field theory（SCFT）.In this model,we assume that the thin block copolymer film is confined in the vicinity of a square-shaped particle by a homopolymer melt,which is equivalent to the poor solvents.Multiple sequences of square-shaped particle-induced copolymer aggregates with different shapes and self-assembled internal morphologies are predicted as functions of the particle size,the structural portion of the copolymer,and the volume fraction of the copolymer.A rich variety of aggregates are found with complex internal self-assembled morphologies including complex structures of the vesicle,with one or several inverted micelle surrounded by the outer monolayer with the particle confined in the core.These results demonstrate that the assemblies of diblock copolymers formed around the square-shaped particle in poor solvents are of immediate interest to the assembly of copolymer and the morphology of biomembrane in the confined environment,as well as to the transitions of vesicles to micelles.展开更多
目的系统评价衰弱和直立性低血压发生风险的关系。方法计算机检索PubMed、EMbase、Web of Science、CBM、CNKI、VIP和WanFang Data数据库,搜集国内外关于衰弱和直立性低血压发生关系的相关性研究,检索时限均从建库至2020年7月7日。由2...目的系统评价衰弱和直立性低血压发生风险的关系。方法计算机检索PubMed、EMbase、Web of Science、CBM、CNKI、VIP和WanFang Data数据库,搜集国内外关于衰弱和直立性低血压发生关系的相关性研究,检索时限均从建库至2020年7月7日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个研究,包括8671例患者。Meta分析结果显示:与非衰弱组相比,衰弱前期[OR=1.04,95%CI=(0.99,1.09),P=0.11]和衰弱[OR=1.02,95%CI=(0.92,1.13),P=0.70]不会增加直立性低血压的患病风险。亚组分析结果显示:采用不同的衰弱评估工具(Fried量表、临床衰弱量表和衰弱指数),不同样本量大小(<500例或者≥500例),不同地区(欧洲、亚洲和美洲),研究对象的不同来源(医院和社区),衰弱均不会增加直立性低血压患病风险。结论当前证据显示,衰弱不会增加直立性低血压的患病风险。受纳入研究数量和质量的限制,上述结论尚需更多高质量研究予以验证。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.20804060)the Research Foundation of Chongqing University of Science and Technology,China(Grant No.CK2013B16)
文摘The self-assembly of diblock copolymers confined around one square-shaped particle is studied systematically within two-dimensional self-consistent field theory（SCFT）.In this model,we assume that the thin block copolymer film is confined in the vicinity of a square-shaped particle by a homopolymer melt,which is equivalent to the poor solvents.Multiple sequences of square-shaped particle-induced copolymer aggregates with different shapes and self-assembled internal morphologies are predicted as functions of the particle size,the structural portion of the copolymer,and the volume fraction of the copolymer.A rich variety of aggregates are found with complex internal self-assembled morphologies including complex structures of the vesicle,with one or several inverted micelle surrounded by the outer monolayer with the particle confined in the core.These results demonstrate that the assemblies of diblock copolymers formed around the square-shaped particle in poor solvents are of immediate interest to the assembly of copolymer and the morphology of biomembrane in the confined environment,as well as to the transitions of vesicles to micelles.
文摘目的系统评价衰弱和直立性低血压发生风险的关系。方法计算机检索PubMed、EMbase、Web of Science、CBM、CNKI、VIP和WanFang Data数据库,搜集国内外关于衰弱和直立性低血压发生关系的相关性研究,检索时限均从建库至2020年7月7日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个研究,包括8671例患者。Meta分析结果显示:与非衰弱组相比,衰弱前期[OR=1.04,95%CI=(0.99,1.09),P=0.11]和衰弱[OR=1.02,95%CI=(0.92,1.13),P=0.70]不会增加直立性低血压的患病风险。亚组分析结果显示:采用不同的衰弱评估工具(Fried量表、临床衰弱量表和衰弱指数),不同样本量大小(<500例或者≥500例),不同地区(欧洲、亚洲和美洲),研究对象的不同来源(医院和社区),衰弱均不会增加直立性低血压患病风险。结论当前证据显示,衰弱不会增加直立性低血压的患病风险。受纳入研究数量和质量的限制,上述结论尚需更多高质量研究予以验证。
