2007 Anniversary Symposium of the State Key Laboratory of Natural and Biomimetic Drugs and The 1^st Round-Table Symposium of Chemical Biology on Nucleic Acid and Carbohydrate was held at Peking University Health Scien...2007 Anniversary Symposium of the State Key Laboratory of Natural and Biomimetic Drugs and The 1^st Round-Table Symposium of Chemical Biology on Nucleic Acid and Carbohydrate was held at Peking University Health Science Center, Oct. 22^sd - 23^rd, 2007. The Anniversary Symposium was presided over by Academician Li-He Zhang. The officials from Ministry of Education, National Natural Science Foundation of China and Peking University Health Science Center presented. Wei-Gang Fang,展开更多
From November 13^rd to 14^th, the 2008 Scientific and Development Symposium of the State Key Laboratory of Natural and Biomimetic Drugs of Peking University was hold at Fragrant Hill Hotel, Beijing. About 90 academici...From November 13^rd to 14^th, the 2008 Scientific and Development Symposium of the State Key Laboratory of Natural and Biomimetic Drugs of Peking University was hold at Fragrant Hill Hotel, Beijing. About 90 academicians, professors, chiefs of the research groups, teachers, officials and students attended the meeting, among them including Prof. Wei-Gang Fang, a deputy director of Peking University Health Science Center; Mr. Ju Ming, a chief of the section, Division of Science and Technology,展开更多
文摘2007 Anniversary Symposium of the State Key Laboratory of Natural and Biomimetic Drugs and The 1^st Round-Table Symposium of Chemical Biology on Nucleic Acid and Carbohydrate was held at Peking University Health Science Center, Oct. 22^sd - 23^rd, 2007. The Anniversary Symposium was presided over by Academician Li-He Zhang. The officials from Ministry of Education, National Natural Science Foundation of China and Peking University Health Science Center presented. Wei-Gang Fang,
文摘From November 13^rd to 14^th, the 2008 Scientific and Development Symposium of the State Key Laboratory of Natural and Biomimetic Drugs of Peking University was hold at Fragrant Hill Hotel, Beijing. About 90 academicians, professors, chiefs of the research groups, teachers, officials and students attended the meeting, among them including Prof. Wei-Gang Fang, a deputy director of Peking University Health Science Center; Mr. Ju Ming, a chief of the section, Division of Science and Technology,
文摘腺苷受体是重要的治疗靶标,选择性腺苷受体拮抗剂具有广泛的临床应用前景.本文通过同源模建构建了腺苷A1、A2B和A3受体的结构,采用Ligand Scout 3.12软件分别构建了腺苷受体四种亚型的拮抗剂药效团模型.然后利用Schr?dinger程序中的Induced Fit Docking模块完成受体-拮抗剂结合模式的预测,并与药效团结果进行比对.结果发现,由于结合口袋部位的残基在家族间高度保守,模建得到的各个亚型受体的初始结构活性口袋部位极为相似,无法用于亚型选择性拮抗剂的识别.而腺苷受体四种亚型拮抗剂药效团的药效特征与空间排布都不同,并与以前突变实验信息相吻合.研究结果说明,结合口袋部位的优化是模建中的关键步骤,基于配体的药效团模型所包含的一系列药效特征元素如氢键受体、氢键供体、疏水基团、芳环中心,可以很好地表征受体结合部位氢键、疏水空腔的位置及其方向.本文研究结果可以为进一步的优化同源模建结果,寻找新型的人类腺苷受体选择性拮抗剂提供理论依据.
