Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ...Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this effect.In this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic analysis.The results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer pain.In addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain hypersensitivity.Furthermore,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 expression.Moreover,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was enhanced.Mechanistically,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ribonucleoprotein-F.Additionally,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 methylation.These findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.展开更多
Comprehensive understanding of the direct transformation pathway from graphite to diamond under high temperature and high pressure has long been one of the fundamental goals in materials science.Despite considerable e...Comprehensive understanding of the direct transformation pathway from graphite to diamond under high temperature and high pressure has long been one of the fundamental goals in materials science.Despite considerable experimental and theoretical progress,current experimental studies have mainly focused on the local microstructural characterizations of recovered samples,which has certain limitations for hightemperature and high-pressure products,which often exhibit diversity.Here,we report on the pressure-induced phase transition behavior of natural single-crystal graphite under three distinct pressure-transmitting media from a macroscopic perspective using in situ two-dimensional Raman spectroscopy,scanning electron microscopy,and atomic force microscopy.The surface evolution process of graphite before and after the phase transition is captured,revealing that pressure-induced surface textures can impede the continuity of the phase transition process across the entire single crystal.Our results provide a fresh perspective for studying the phase transition behavior of graphite and greatly deepen our understanding of this behavior,which will be helpful in guiding further high-temperature and high-pressure syntheses of carbon allotropes.展开更多
Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containin...Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.展开更多
The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practi...The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practical interest.However,academia and industry have used a variety of interpretations,and the scientific literature lacks a unified and consistent definition of this term.The purpose of this study is to systematically examine the definitional landscape of the digital twin concept as outlined in scholarly literature,beginning with its origins in the aerospace domain and extending to its contemporary interpretations in the manufacturing industry.Notably,this investigationwill focus on the research conducted on Industry 4.0 and smartmanufacturing,elucidating the diverse applications of digital twins in fields including aerospace,intelligentmanufacturing,intelligent transportation,and intelligent cities,among others.展开更多
With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and...With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and tuina undergraduates of Yunnan University of Traditional Chinese Medicine.The employment concept of acupuncture and tuina undergraduates in the minority border areas has changed greatly.After graduation,97.95%of students choose to work in fields related to medicine and acupuncture,prefer positions close to home,and are attracted to high-salary companies,among other factors.Therefore,enhancing the competitive advantages of medical students by guiding their career planning,providing employment selection advice,fostering innovation and entrepreneurship,improving basic skills,and offering graduate entrance examination guidance is crucial for broadening their employment opportunities.展开更多
The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological c...The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological crisis.The research mainly adopts case study and interview methods.Through scientific analysis of psychological crisis cases in four grades of X College in ethnic regions,it summarizes the current situation of crisis psychology among X College students,hoping to provide some first-hand data and research ideas for relevant researchers.展开更多
Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prev...Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prevalence of meeting the 24-h movement guidelines,its correlates,and its relationships with body mass index in children and adolescents in China.Methods:Cross-sectional data from the 2017 Youth Study in China of 114,072 children and adolescents(mean age=13.75 years,49.18%boys)were used.Meeting 24-h movement guidelines(60 min of daily moderate-to-vigorous physical activity,2 h of daily leisure screen time,911 h and 810 h nightly sleep duration for 613-year-olds and 1417-year-olds,respectively)and height and weight of all participants were assessed.The prevalence of meeting the 24-h movement guidelines and World Health Organization weight status categories were determined.Generalized linear models were used to determine the correlates of meeting the 24-h movement guidelines and the relationships of meeting the 24-h movement guidelines with overweight(OW)and obesity(OB).Results:Only 5.12%of Chinese children and adolescents met the 24-h movement guidelines,and 22.44%were classified as OW/OB.Older children and adolescents were less likely to meet the 24-h movement guidelines.Parental education level and family income were positively related to meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines showed lower odds ratios for OW/OB.Compared with participants meeting the 24-h movement guidelines,boys in 4th6th grades met none of the recommendations(OR=1.22,95%CI:1.061.40),met the screen time recommendation only(OR=1.13,95%CI:1.011.28),met the nightly sleep duration recommendation only(OR=1.14,95%CI:1.031.28),and had significantly higher odds ratios for OW/OB.Similar trends were observed for girls in 4th6th grades:meeting none of the guidelines(OR=1.35,95%CI:1.141.59),meeting sleep duration guidelines only(OR=1.23,95%CI:1.081.39),and meeting moderate-to-vigorous physical activity+nightly sleep duration guidelines(OR=1.24,95%CI:1.011.54).For girls in 7th9th grades,the following trend was observed:meeting none of the guidelines(OR=1.30,95%CI:1.011.67).Conclusion:Very few Chinese children and adolescents met the 24-h movement guidelines.Age(negatively correlated),parental education level,and family income(both positively correlated)were correlates of meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines were more likely to have lower risks for OW/OB,especially in the youngest age group(Grades 46);and girls in the middle age group(Grades 79)were also more likely to have lower risks for OW/OB.Further research studies should explore additional correlates and determinants for meeting the 24-h movement guidelines.Also,future studies should use longitudinal or interventional designs to determine the relationships between meeting the 24-h movement guidelines and OW/OB and other health indicators,while taking sex and age differences into account.展开更多
Purpose: The purpose of this study was to examine the association between school and community physical activity(PA) characteristics and levels of moderate-to-vigorous physical activity(MVPA) among Chinese school chil...Purpose: The purpose of this study was to examine the association between school and community physical activity(PA) characteristics and levels of moderate-to-vigorous physical activity(MVPA) among Chinese school children.Methods: Data were obtained from the 2016 Physical Activity and Fitness in China—The Youth Study project. Participants were 80,928 school children(Grades 4–12; 39,747 boys, 41,181 girls; mean age = 13 years) and 935 physical education(PE) teachers who completed a study survey.Independent variables included both school-related factors(school-level PA support, availability of and access to PA facilities, and the duration of school PE classes) and community-related factors(the frequency of sports events, sports training opportunities, availability of sports clubs and organizations, and access to PA facilities). The dependent variable was the children's self-reported participation in MVPA. The data were analyzed,in 2017, via multilevel modeling.Results: PA support from school administrators was the only school-level factor significantly related to children's participation in MVPA.Children's perceptions of the frequency of community-sponsored sports events, availability of sports clubs and organizations, and convenient access to PA facilities were associated with a high level of MVPA participation. In regard to residency in urban and rural areas, children attending urban schools who perceived high availability of PA facilities were associated with a low level of participation in MVPA.Conclusion: School support for PA and community PA resources are associated with MVPA among Chinese school children. School PA facilities appear underutilized among urban schools as evidenced by low levels of MVPA among school children.展开更多
Purpose This study aimed to describe the national prevalence of Chinese children and adolescents who met the World Health Organization muscle-strengthening exercise(MSE)recommendations and identify correlates of meeti...Purpose This study aimed to describe the national prevalence of Chinese children and adolescents who met the World Health Organization muscle-strengthening exercise(MSE)recommendations and identify correlates of meeting the MSE recommendations.Methods Cross-sectional data from the 2019 Physical Activity and Fitness in China—The Youth Study,a nationally representative sample of Chinese children and adolescents(n=80,413;mean age=13.7 years;53.9%girls)and their parents,were analyzed.Children and adolescents who reported engaging≥3 days(up to 7 days)of MSE per week were classified as meeting the MSE recommendations.MSE,demographics,lifestyle behaviors(sport participation,moderate-to-vigorous physical activity,screen time,and sleep duration),exercise intention,peer and parental support,and parental MSE participation were assessed through self-reports.Logistic regression models were used to determine the correlates of meeting the MSE recommendations.The analyses were completed in 2020.Results Overall,39.3%of children and adolescents met the MSE recommendations.Girls,10th-12th graders,minorities,those from lower income households and those from families with lower parental education were less likely to meet the MSE recommendations.Children and adolescents who were proficient in≥2 sports were more likely to meet the MSE recommendations(adjusted odds ratio(aOR)=1.44,95%confidence interval(95%CI):1.26-1.65),as were those with more moderate-to-vigorous physical activity(aOR=1.57,95%CI:1.53-1.61).Additionally,children and adolescents with high exercise intention(aOR=1.60,95%CI:1.51-1.69),those whose parents met the adult MSE recommendations(aOR=1.46,95%CI:1.40-1.52),and those who received high peer(aOR=1.27,95%CI:1.20-1.34)and parental support(aOR=1.07,95%CI:1.04-1.12)were more likely to meet the MSE recommendations.Conclusion Less than two-fifths of Chinese children and adolescents met the World Health Organization MSE recommendations.The correlates identified in our study can help inform the development of school and community based strategies and policies to enhance participation in MSE and improve muscular fitness of all Chinese children and adolescents.展开更多
The extension of the suture zone between the Siberian and Kazakhstan continents in China has been a matter of debate because few outcrops of ophiolitic melange have been found so far. The recently found Tuerkubantao o...The extension of the suture zone between the Siberian and Kazakhstan continents in China has been a matter of debate because few outcrops of ophiolitic melange have been found so far. The recently found Tuerkubantao ophiolitic melange, which is located east of the Kekesentao Mt. in the Buer- jin County of the Chinese Altay, provides an important clue for this problem. This paper presents the results of field investigation, petrology, U-Pb isotope dating of zircons and bulk-rock geochemistry of the Tuerkubantao melange rocks. The melange consists of fault-contacted ultramafic rocks, gabbro, diabase, basalt, flysch and granitoids. The ultramafic-mafic rocks are Mg-rich （Mg#= 4.25-6.35） and w（SiO2） spans 38.8%--46.8%. Basalt and gabbro are geochemically similar and are characterized by low w（FeOt） （10.9%）, total alkali w（Na20 ＋ K20） = 2.58%） and w（TiO2） （1.17%） and affinity to the Mg-rich tholeiite series. The flat REE and trace-element patterns of the ultramafic-mafic rocks are indic- ative of their ophiolite origin, i.e., formation in a mid-oceanic ridge setting. The fragments of low-K gneissic granite formed in suprasubduction or syn-collisional setting. Zircons from gabbro and gneissic granite yielded U-Pb ages of 363 and 355 Ma, respectively, suggesting Late Devonian mid-oceanic spreading and oceanic subduction accompanied by suprasubduction magmatism. The Tuerkubantao ophiolite together with the Qiaoxiahala and Buergen ophiolites of the Kekesentao belt define an ophiolitic melange belt extending along the Erqis fault. This belt probably belongs to the Ural- Zaisan-South Mongolian suture-shear zone formed during the subduction of the Paleo-Asian Ocean and subsequent collision of the Siberian and Kazakhstan continents.展开更多
Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical sh...Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical shortfalls, especially the undesirable activity and durability issues of electrocatalysts toward methanol oxidation reaction. In light of these challenges, the inherent advantages of unsupported Pt based nanostructures demonstrate their great potentials as durable and efficient electrocatalysts for direct methanol fuel cells. This review will summarize recent achievements of unsupported Pt-based electrocatalysts toward methanol oxidation, with highlighting the interactions between the performance and structure tailoring and composition modulating. At last, a perspective is proposed for the upcoming challenges and possible opportunities to further prompt the practical application of unsupported Pt-based electrocatalysts for direct methanol fuel cells.展开更多
The establishment of the upper-level South Asian high （SAH） over the Indo-China Peninsula （ICP） during late boreal spring and its possible causes are investigated using long-term NCEP-NCAR and ERA-40 reanalysis an...The establishment of the upper-level South Asian high （SAH） over the Indo-China Peninsula （ICP） during late boreal spring and its possible causes are investigated using long-term NCEP-NCAR and ERA-40 reanalysis and satellite-observed OLR data. Results show that, from early March to mid-April, deep convection stays south of -6°N over the northern Sumatran islands. As the maximum solar radiation moves over the latitudes of the ICP （10-20°N） in late April, the air over the ICP becomes unstable. It ascends over the ICP and descends over the adjacent waters to the east and west. This triggers deep convection over the ICP that induces large latent heating and strong updrafts and upper-level divergence, leading to the formation of an upper-level anticyclonic circulation and the SAH over the ICE During early to mid-May, deep convection over the ICP intensifies and extends northwards to the adjacent waters. Strong latent heating from deep convection enhances and maintains the strong updrafts and upper-level divergence, and the SAH is fully established by mid-May. Thus, the seasonal maximum solar heating and the land-sea contrast around the ICP provide the basic conditions for deep convection to occur preferentially over the ICP, which leads to the formation of the SAH over the ICP from late April to mid-May. Simulations using RegCM4 also indicate that the diabatic heating over the ICP is conducive to the generation and development of upper-level anticyclonic circulation, which leads to an earlier establishment of the SAH.展开更多
In this paper, by applying the technique of the sharp maximal function and the equivalent representation of the norm in the Lebesgue spaces with variable exponent, the boundedness of the parameterized Litflewood-Paley...In this paper, by applying the technique of the sharp maximal function and the equivalent representation of the norm in the Lebesgue spaces with variable exponent, the boundedness of the parameterized Litflewood-Paley operators, including the parameterized Lusin area integrals and the parameterized Littlewood-Paley gλ^＊- functions, is established on the Lebesgue spaces with variable exponent. Furthermore, the boundedness of their commutators generated respectively by BMO functions and Lipschitz functions are also obtained.展开更多
The southeastern margin of Qinghai-Tibet Plateau(SMQTP)is of a typical large landslide-prone area due to intense tectonic activity,deeply incised valleys,high geostress and frequent earthquakes.To gain insights into l...The southeastern margin of Qinghai-Tibet Plateau(SMQTP)is of a typical large landslide-prone area due to intense tectonic activity,deeply incised valleys,high geostress and frequent earthquakes.To gain insights into large landslides in southeastern margin of Qinghai-Tibet Plateau,an area covering 3.34×105 km2 that extends 80e150 km on both sides of the Sichuan-Tibet traffic corridors(G318)was used to examine the spatial distribution and corresponding characteristics of landslides.The results showed that the study area contains at least 629 large landslides that are mainly concentrated on 7 zones(zones IeVII).Zones IeVII are in the southern section of the Longmenshan fault zone(with no large river)and sections with Dadu River,Jinsha River,Lancang River,Nujiang River and Yarlung Zangbo River.There are more landslides in the Jinsha River section(totaling 186 landslides)than the other sections.According to the updated Varnes classification,408 large landslides(64.9%)were recognized and divided into 4 major types,i.e.flows(275 cases),slides(58 cases),topples(44 cases)and slope deformations(31 cases).Flows,which consist of rock avalanches and iceerock avalanches,are the most common landslide type.Large landslide triggers(178 events,28.3%)are also recognized,and earthquakes may be the most common trigger.Due to the limited data,these landslide type classifications and landslide triggers are perhaps immature,and further systematic analysis is needed.展开更多
Objective:The aim of this study was to investigate the mechanism of acupotomology(Apo)in the prevention of articular cartilage destruction via the promotion of chondrocyte proliferation and chondrocyte expression of c...Objective:The aim of this study was to investigate the mechanism of acupotomology(Apo)in the prevention of articular cartilage destruction via the promotion of chondrocyte proliferation and chondrocyte expression of cell cycle regulators,CyclinD1,CDK4 and CDK6 in a rabbit knee osteoarthritis(KOA)model.Methods:Twenty-eight rabbits were randomly divided into a control group,an OA(osteoarthritis)model group,an Apo(acupotomology)group and EA(electro-acupuncture)group(n Z 7).Improved Videman’s method was used to induce a rabbit model of KOA over 6 weeks.One week later,acupotomy and electro-acupuncture therapy was applied to animals in the respective groups and treatment lasted 4 weeks.Following these treatments,quantitative real-time PCR,immunohistochemical staining and western blotting were performed to assess the mRNA and protein levels of cell cycle regulators CyclinD1(Cell cycle protein D1),CDK4(Cyclin-dependent kinase 4)and CDK6(Cyclin-dependent kinase 6).Ethology measures and knee morphology were also compared among groups.Results:The Lequesne MG index score of morphology was increased(P<.01),and the passive range of motion(PROM)and the mRNA and protein levels of CyclinD1,CDK4,and CDK6 were significantly decreased(P<.01)in the OA model compared with the control group.The Lequesne MG index score and the morphology score were decreased in the Apo and EA group compared with the OA model group(P<.05 or P<.01),while the mRNA levels of CyclinD1,CDK4,and CDK6,and the protein levels of CDK4 were increased in the Apo and EA groups compared with the OA model group(P<.05 or P<.01).The PROM,and the protein levels of CyclinD1 and CDK6 were increased(P<.05)in the Apo group compared with the OA model group,while the PROM and the protein levels of CyclinD1 and CDK6 in the EA group were not significantly different(P>.05).Compared with the EA group,the morphology score was decreased in Apo group(P<.05).Conclusions:The mRNA levels of CyclinD1 and CDK4,and the protein level of CDK4 in chondrocytes are regulate by both Apo and EA.Apo is more effective than EA in regulating the protein levels of CyclinD1 and CDK6.According to the observed changes in morphology and cytokine levels,acupotomy can promote chondrocyte proliferation and can alleviate the destruction of articular cartilage in a model of KOA.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82001178(to LW),81901129(to LH),82001175(to FX)Shanghai Sailing Program,No.20YF1439200(to LW)+1 种基金the Natural Science Foundation of Shanghai,China,No.23ZR1450800(to LH)and the Fundamental Research Funds for the Central Universities,No.YG2023LC15(to ZX)。
文摘Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this effect.In this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic analysis.The results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer pain.In addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain hypersensitivity.Furthermore,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 expression.Moreover,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was enhanced.Mechanistically,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ribonucleoprotein-F.Additionally,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 methylation.These findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.
基金support from the National Science Fund for Distinguished Young Scholars(Grant No.T2225027)the NSAF(Grant No.U1930401)+1 种基金the National Key R&D Program of China(MOST)(Grant No.2023YFA1406500)the National Natural Science Foundation of China(NSFC)(Grant No.61674045).
文摘Comprehensive understanding of the direct transformation pathway from graphite to diamond under high temperature and high pressure has long been one of the fundamental goals in materials science.Despite considerable experimental and theoretical progress,current experimental studies have mainly focused on the local microstructural characterizations of recovered samples,which has certain limitations for hightemperature and high-pressure products,which often exhibit diversity.Here,we report on the pressure-induced phase transition behavior of natural single-crystal graphite under three distinct pressure-transmitting media from a macroscopic perspective using in situ two-dimensional Raman spectroscopy,scanning electron microscopy,and atomic force microscopy.The surface evolution process of graphite before and after the phase transition is captured,revealing that pressure-induced surface textures can impede the continuity of the phase transition process across the entire single crystal.Our results provide a fresh perspective for studying the phase transition behavior of graphite and greatly deepen our understanding of this behavior,which will be helpful in guiding further high-temperature and high-pressure syntheses of carbon allotropes.
基金supported by Health Commission of Pudong New Area Health and Family Planning Scientific Research Project,No.PW2020E-4(to GL)Siming Youth Fund Project of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,No.SGKJ-202119(to RH)+5 种基金Medical Innovation Research Special Project of 2021“Science and Technology Innovation Action Plan”of Shanghai,No.21Y21920200(to GL)Shanghai Rising-Star Program and Shanghai Sailing Program,No.23YF1418200(to QH)Shanghai Municipal Health Commission Foundation grant,No.20234Y0294(to QH)Hundred Teacher Talent Program of Shanghai University of Medicine and Health Sciences,No.A1-2601-23-311007-21(to QH)the Scientific and Technological Innovation Program of Higher Education Institution in Shanxi,No.2021L350(to XC)the Fundamental Research Program of Shanxi Province,No.20210302124194(to XC).
文摘Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.
基金This research is supported by National Natural Science Foundation of China(No.61902158).
文摘The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practical interest.However,academia and industry have used a variety of interpretations,and the scientific literature lacks a unified and consistent definition of this term.The purpose of this study is to systematically examine the definitional landscape of the digital twin concept as outlined in scholarly literature,beginning with its origins in the aerospace domain and extending to its contemporary interpretations in the manufacturing industry.Notably,this investigationwill focus on the research conducted on Industry 4.0 and smartmanufacturing,elucidating the diverse applications of digital twins in fields including aerospace,intelligentmanufacturing,intelligent transportation,and intelligent cities,among others.
文摘With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and tuina undergraduates of Yunnan University of Traditional Chinese Medicine.The employment concept of acupuncture and tuina undergraduates in the minority border areas has changed greatly.After graduation,97.95%of students choose to work in fields related to medicine and acupuncture,prefer positions close to home,and are attracted to high-salary companies,among other factors.Therefore,enhancing the competitive advantages of medical students by guiding their career planning,providing employment selection advice,fostering innovation and entrepreneurship,improving basic skills,and offering graduate entrance examination guidance is crucial for broadening their employment opportunities.
基金Self-funded project“Research on Intervention Pathways for Psychological Crisis of College Students in Ethnic Regions”by Sichuan Minzu College(Project number:XYZB2328SB)。
文摘The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological crisis.The research mainly adopts case study and interview methods.Through scientific analysis of psychological crisis cases in four grades of X College in ethnic regions,it summarizes the current situation of crisis psychology among X College students,hoping to provide some first-hand data and research ideas for relevant researchers.
基金the Key Project of the National Social Science Foundation of China(No.16ZDA227)The first and corresponding authors(STC and YL)are supported by grants from the National Social Science Foundation of China(No.19BTY077)+1 种基金the Philosophy and Social Science Foundation of Shanghai(No.A1904)the Shanghai Key Laboratory of Human Performance(Shanghai University of Sport,No.11DZ2261100)。
文摘Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prevalence of meeting the 24-h movement guidelines,its correlates,and its relationships with body mass index in children and adolescents in China.Methods:Cross-sectional data from the 2017 Youth Study in China of 114,072 children and adolescents(mean age=13.75 years,49.18%boys)were used.Meeting 24-h movement guidelines(60 min of daily moderate-to-vigorous physical activity,2 h of daily leisure screen time,911 h and 810 h nightly sleep duration for 613-year-olds and 1417-year-olds,respectively)and height and weight of all participants were assessed.The prevalence of meeting the 24-h movement guidelines and World Health Organization weight status categories were determined.Generalized linear models were used to determine the correlates of meeting the 24-h movement guidelines and the relationships of meeting the 24-h movement guidelines with overweight(OW)and obesity(OB).Results:Only 5.12%of Chinese children and adolescents met the 24-h movement guidelines,and 22.44%were classified as OW/OB.Older children and adolescents were less likely to meet the 24-h movement guidelines.Parental education level and family income were positively related to meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines showed lower odds ratios for OW/OB.Compared with participants meeting the 24-h movement guidelines,boys in 4th6th grades met none of the recommendations(OR=1.22,95%CI:1.061.40),met the screen time recommendation only(OR=1.13,95%CI:1.011.28),met the nightly sleep duration recommendation only(OR=1.14,95%CI:1.031.28),and had significantly higher odds ratios for OW/OB.Similar trends were observed for girls in 4th6th grades:meeting none of the guidelines(OR=1.35,95%CI:1.141.59),meeting sleep duration guidelines only(OR=1.23,95%CI:1.081.39),and meeting moderate-to-vigorous physical activity+nightly sleep duration guidelines(OR=1.24,95%CI:1.011.54).For girls in 7th9th grades,the following trend was observed:meeting none of the guidelines(OR=1.30,95%CI:1.011.67).Conclusion:Very few Chinese children and adolescents met the 24-h movement guidelines.Age(negatively correlated),parental education level,and family income(both positively correlated)were correlates of meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines were more likely to have lower risks for OW/OB,especially in the youngest age group(Grades 46);and girls in the middle age group(Grades 79)were also more likely to have lower risks for OW/OB.Further research studies should explore additional correlates and determinants for meeting the 24-h movement guidelines.Also,future studies should use longitudinal or interventional designs to determine the relationships between meeting the 24-h movement guidelines and OW/OB and other health indicators,while taking sex and age differences into account.
基金supported by the Key Project of the National Social Science Foundation of China (No.16ZDA227)
文摘Purpose: The purpose of this study was to examine the association between school and community physical activity(PA) characteristics and levels of moderate-to-vigorous physical activity(MVPA) among Chinese school children.Methods: Data were obtained from the 2016 Physical Activity and Fitness in China—The Youth Study project. Participants were 80,928 school children(Grades 4–12; 39,747 boys, 41,181 girls; mean age = 13 years) and 935 physical education(PE) teachers who completed a study survey.Independent variables included both school-related factors(school-level PA support, availability of and access to PA facilities, and the duration of school PE classes) and community-related factors(the frequency of sports events, sports training opportunities, availability of sports clubs and organizations, and access to PA facilities). The dependent variable was the children's self-reported participation in MVPA. The data were analyzed,in 2017, via multilevel modeling.Results: PA support from school administrators was the only school-level factor significantly related to children's participation in MVPA.Children's perceptions of the frequency of community-sponsored sports events, availability of sports clubs and organizations, and convenient access to PA facilities were associated with a high level of MVPA participation. In regard to residency in urban and rural areas, children attending urban schools who perceived high availability of PA facilities were associated with a low level of participation in MVPA.Conclusion: School support for PA and community PA resources are associated with MVPA among Chinese school children. School PA facilities appear underutilized among urban schools as evidenced by low levels of MVPA among school children.
基金supported by the Key Project of the National Social Science Foundation of China (No.18ATY008)
文摘Purpose This study aimed to describe the national prevalence of Chinese children and adolescents who met the World Health Organization muscle-strengthening exercise(MSE)recommendations and identify correlates of meeting the MSE recommendations.Methods Cross-sectional data from the 2019 Physical Activity and Fitness in China—The Youth Study,a nationally representative sample of Chinese children and adolescents(n=80,413;mean age=13.7 years;53.9%girls)and their parents,were analyzed.Children and adolescents who reported engaging≥3 days(up to 7 days)of MSE per week were classified as meeting the MSE recommendations.MSE,demographics,lifestyle behaviors(sport participation,moderate-to-vigorous physical activity,screen time,and sleep duration),exercise intention,peer and parental support,and parental MSE participation were assessed through self-reports.Logistic regression models were used to determine the correlates of meeting the MSE recommendations.The analyses were completed in 2020.Results Overall,39.3%of children and adolescents met the MSE recommendations.Girls,10th-12th graders,minorities,those from lower income households and those from families with lower parental education were less likely to meet the MSE recommendations.Children and adolescents who were proficient in≥2 sports were more likely to meet the MSE recommendations(adjusted odds ratio(aOR)=1.44,95%confidence interval(95%CI):1.26-1.65),as were those with more moderate-to-vigorous physical activity(aOR=1.57,95%CI:1.53-1.61).Additionally,children and adolescents with high exercise intention(aOR=1.60,95%CI:1.51-1.69),those whose parents met the adult MSE recommendations(aOR=1.46,95%CI:1.40-1.52),and those who received high peer(aOR=1.27,95%CI:1.20-1.34)and parental support(aOR=1.07,95%CI:1.04-1.12)were more likely to meet the MSE recommendations.Conclusion Less than two-fifths of Chinese children and adolescents met the World Health Organization MSE recommendations.The correlates identified in our study can help inform the development of school and community based strategies and policies to enhance participation in MSE and improve muscular fitness of all Chinese children and adolescents.
基金supported by the Major State Basic Research Program of the People's Republic of China(Nos.2007CB411304 and 2001CB409806)
文摘The extension of the suture zone between the Siberian and Kazakhstan continents in China has been a matter of debate because few outcrops of ophiolitic melange have been found so far. The recently found Tuerkubantao ophiolitic melange, which is located east of the Kekesentao Mt. in the Buer- jin County of the Chinese Altay, provides an important clue for this problem. This paper presents the results of field investigation, petrology, U-Pb isotope dating of zircons and bulk-rock geochemistry of the Tuerkubantao melange rocks. The melange consists of fault-contacted ultramafic rocks, gabbro, diabase, basalt, flysch and granitoids. The ultramafic-mafic rocks are Mg-rich （Mg#= 4.25-6.35） and w（SiO2） spans 38.8%--46.8%. Basalt and gabbro are geochemically similar and are characterized by low w（FeOt） （10.9%）, total alkali w（Na20 ＋ K20） = 2.58%） and w（TiO2） （1.17%） and affinity to the Mg-rich tholeiite series. The flat REE and trace-element patterns of the ultramafic-mafic rocks are indic- ative of their ophiolite origin, i.e., formation in a mid-oceanic ridge setting. The fragments of low-K gneissic granite formed in suprasubduction or syn-collisional setting. Zircons from gabbro and gneissic granite yielded U-Pb ages of 363 and 355 Ma, respectively, suggesting Late Devonian mid-oceanic spreading and oceanic subduction accompanied by suprasubduction magmatism. The Tuerkubantao ophiolite together with the Qiaoxiahala and Buergen ophiolites of the Kekesentao belt define an ophiolitic melange belt extending along the Erqis fault. This belt probably belongs to the Ural- Zaisan-South Mongolian suture-shear zone formed during the subduction of the Paleo-Asian Ocean and subsequent collision of the Siberian and Kazakhstan continents.
基金financial supported by National 1000 Young Talents Program of ChinaNation Natural Science Foundation of China(21473111)+2 种基金The Innovation Foundation of Shenzhen Government(JCYJ20160408173202143)the Joint Fund of Energy Storage of Qingdao(20160012)the Innovation Research Funds of HUST(3004013109,0118013089,and 2017KFYXJJ164)
文摘Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical shortfalls, especially the undesirable activity and durability issues of electrocatalysts toward methanol oxidation reaction. In light of these challenges, the inherent advantages of unsupported Pt based nanostructures demonstrate their great potentials as durable and efficient electrocatalysts for direct methanol fuel cells. This review will summarize recent achievements of unsupported Pt-based electrocatalysts toward methanol oxidation, with highlighting the interactions between the performance and structure tailoring and composition modulating. At last, a perspective is proposed for the upcoming challenges and possible opportunities to further prompt the practical application of unsupported Pt-based electrocatalysts for direct methanol fuel cells.
基金jointly supported by the Major Program of the Natural Science Researches for Colleges and Universities in Jiangsu Province(Grant No.14KJA170004)the Natural Science Foundation of Jiangsu Province(Grant No.BK20131432)+5 种基金the“333”Project of Jiangsu Province“Qing Lan”Project of Jiangsu Provincethe Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)supported by the U.S.National Science Foundation(Grant No.AGS-1353740)the U.S.Department of Energy’s Office of Science(Grant No.DE-SC0012602)the U.S.National Oceanic and Atmospheric Administration(Grant No.NA15OAR4310086)
文摘The establishment of the upper-level South Asian high （SAH） over the Indo-China Peninsula （ICP） during late boreal spring and its possible causes are investigated using long-term NCEP-NCAR and ERA-40 reanalysis and satellite-observed OLR data. Results show that, from early March to mid-April, deep convection stays south of -6°N over the northern Sumatran islands. As the maximum solar radiation moves over the latitudes of the ICP （10-20°N） in late April, the air over the ICP becomes unstable. It ascends over the ICP and descends over the adjacent waters to the east and west. This triggers deep convection over the ICP that induces large latent heating and strong updrafts and upper-level divergence, leading to the formation of an upper-level anticyclonic circulation and the SAH over the ICE During early to mid-May, deep convection over the ICP intensifies and extends northwards to the adjacent waters. Strong latent heating from deep convection enhances and maintains the strong updrafts and upper-level divergence, and the SAH is fully established by mid-May. Thus, the seasonal maximum solar heating and the land-sea contrast around the ICP provide the basic conditions for deep convection to occur preferentially over the ICP, which leads to the formation of the SAH over the ICP from late April to mid-May. Simulations using RegCM4 also indicate that the diabatic heating over the ICP is conducive to the generation and development of upper-level anticyclonic circulation, which leads to an earlier establishment of the SAH.
基金supported by National Natural Foundation of China (Grant Nos. 11161042 and 11071250)
文摘In this paper, by applying the technique of the sharp maximal function and the equivalent representation of the norm in the Lebesgue spaces with variable exponent, the boundedness of the parameterized Litflewood-Paley operators, including the parameterized Lusin area integrals and the parameterized Littlewood-Paley gλ^＊- functions, is established on the Lebesgue spaces with variable exponent. Furthermore, the boundedness of their commutators generated respectively by BMO functions and Lipschitz functions are also obtained.
基金This study was supported by the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2021QZKK0202)the China Postdoctoral Science Foundation(Grant No.2021T140650)the National Natural Science Foundation of China(Grant No.42007273).The authors express their gratitude for this financial assistance.
文摘The southeastern margin of Qinghai-Tibet Plateau(SMQTP)is of a typical large landslide-prone area due to intense tectonic activity,deeply incised valleys,high geostress and frequent earthquakes.To gain insights into large landslides in southeastern margin of Qinghai-Tibet Plateau,an area covering 3.34×105 km2 that extends 80e150 km on both sides of the Sichuan-Tibet traffic corridors(G318)was used to examine the spatial distribution and corresponding characteristics of landslides.The results showed that the study area contains at least 629 large landslides that are mainly concentrated on 7 zones(zones IeVII).Zones IeVII are in the southern section of the Longmenshan fault zone(with no large river)and sections with Dadu River,Jinsha River,Lancang River,Nujiang River and Yarlung Zangbo River.There are more landslides in the Jinsha River section(totaling 186 landslides)than the other sections.According to the updated Varnes classification,408 large landslides(64.9%)were recognized and divided into 4 major types,i.e.flows(275 cases),slides(58 cases),topples(44 cases)and slope deformations(31 cases).Flows,which consist of rock avalanches and iceerock avalanches,are the most common landslide type.Large landslide triggers(178 events,28.3%)are also recognized,and earthquakes may be the most common trigger.Due to the limited data,these landslide type classifications and landslide triggers are perhaps immature,and further systematic analysis is needed.
基金the National Natural Science Foundation of China program(No.81574067).
文摘Objective:The aim of this study was to investigate the mechanism of acupotomology(Apo)in the prevention of articular cartilage destruction via the promotion of chondrocyte proliferation and chondrocyte expression of cell cycle regulators,CyclinD1,CDK4 and CDK6 in a rabbit knee osteoarthritis(KOA)model.Methods:Twenty-eight rabbits were randomly divided into a control group,an OA(osteoarthritis)model group,an Apo(acupotomology)group and EA(electro-acupuncture)group(n Z 7).Improved Videman’s method was used to induce a rabbit model of KOA over 6 weeks.One week later,acupotomy and electro-acupuncture therapy was applied to animals in the respective groups and treatment lasted 4 weeks.Following these treatments,quantitative real-time PCR,immunohistochemical staining and western blotting were performed to assess the mRNA and protein levels of cell cycle regulators CyclinD1(Cell cycle protein D1),CDK4(Cyclin-dependent kinase 4)and CDK6(Cyclin-dependent kinase 6).Ethology measures and knee morphology were also compared among groups.Results:The Lequesne MG index score of morphology was increased(P<.01),and the passive range of motion(PROM)and the mRNA and protein levels of CyclinD1,CDK4,and CDK6 were significantly decreased(P<.01)in the OA model compared with the control group.The Lequesne MG index score and the morphology score were decreased in the Apo and EA group compared with the OA model group(P<.05 or P<.01),while the mRNA levels of CyclinD1,CDK4,and CDK6,and the protein levels of CDK4 were increased in the Apo and EA groups compared with the OA model group(P<.05 or P<.01).The PROM,and the protein levels of CyclinD1 and CDK6 were increased(P<.05)in the Apo group compared with the OA model group,while the PROM and the protein levels of CyclinD1 and CDK6 in the EA group were not significantly different(P>.05).Compared with the EA group,the morphology score was decreased in Apo group(P<.05).Conclusions:The mRNA levels of CyclinD1 and CDK4,and the protein level of CDK4 in chondrocytes are regulate by both Apo and EA.Apo is more effective than EA in regulating the protein levels of CyclinD1 and CDK6.According to the observed changes in morphology and cytokine levels,acupotomy can promote chondrocyte proliferation and can alleviate the destruction of articular cartilage in a model of KOA.
