Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of...Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of“Guidance for maternal and fctal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital".This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection diagnostic criteria,inspection precautions,drug treatment options,indications and methods of termination of pregnancy,postpartum fever,breastfeeding considerations,mode of mother-to-child transmission,neonatal isolation and advice on nconatal nursing,to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns.展开更多
Objective This study aimed to explore the clinical value of Children Neuropsychological and Behavioral Scale-Revision 2016(CNBS-R2016)for Autism Spectrum Disorder(ASD)screening in the presence of developmental surveil...Objective This study aimed to explore the clinical value of Children Neuropsychological and Behavioral Scale-Revision 2016(CNBS-R2016)for Autism Spectrum Disorder(ASD)screening in the presence of developmental surveillance.Methods All participants were evaluated by the CNBS-R2016 and Gesell Developmental Schedules(GDS).Spearman’s correlation coefficients and Kappa values were obtained.Taking GDS as a reference assessment,the performance of the CNBS-R2016 for detecting the developmental delays of children with ASD was analyzed with receiver operating characteristic(ROC)curves.The efficacy of the CNBS-R2016 to screen for ASD was explored by comparing Communication Warning Behavior with Autism Diagnostic Observation Schedule,Second Edition(ADOS-2).Results In total,150 children aged 12–42 months with ASD were enrolled.The developmental quotients of the CNBS-R2016 were correlated with those of the GDS(r=0.62–0.94).The CNBS-R2016 and GDS had good diagnostic agreement for developmental delays(Kappa=0.73–0.89),except for Fine Motor.There was a significant difference between the proportions of Fine Motor,delays detected by the CNBS-R2016 and GDS(86.0%vs.77.3%).With GDS as a standard,the areas under the ROC curves of the CNBS-R2016 were above 0.95 for all the domains except Fine Motor,which was 0.70.In addition,the positive rate of ASD was 100.0%and 93.5%when the cut-off points of 7 and 12 in the Communication Warning Behavior subscale were used,respectively.Conclusion The CNBS-R2016 performed well in developmental assessment and screening for children with ASD,especially by Communication Warning Behaviors subscale.Therefore,the CNBS-R2016 is worthy of clinical application in children with ASD in China.展开更多
Background： The Wenchuan earthquake in China caused shock and grief worldwide. Sudden bereavement caused by the earthquake led to physical disorders as well as psychological disturbances in the bereaved individuals. ...Background： The Wenchuan earthquake in China caused shock and grief worldwide. Sudden bereavement caused by the earthquake led to physical disorders as well as psychological disturbances in the bereaved individuals. The bereaved had a high risk for complicated grief （CG）, which may have led to significant distress and impairment in their health. However, there was few available studies on CG among disaster-bereaved individuals in China after the disaster. The aim of this study was to identify factors （demographic characteristics and disaster-related variables） associated with symptoms of CG among the bereaved 18 months after the Wenchuan earthquake. Methods： This study was conducted with a cross-sectional design and a convenience sample of 271 bereaved individuals from three of the hardest hit areas. Data were collected by questionnaires and the instruments used in the study were： General questionnaire and Inventory of CG （ICG）. Multivariate linear regression analysis was used to identify factors associated with symptoms of CG. Results： The mean score on ICG was 52.77 （standard deviation： 10.00）. Being female and loss of a child were related to higher level of CG while having another child after the disaster and receiving psychological counseling experience were associated with lower level of CG. Forty-nine percent of the variance of CG was explained by these identified factors. Conclusions： Eighteen months after the Wenchuan earthquake, the symptoms of CG among the bereaved were higher than the previous studies with bereaved individuals. This study uncovers a vulnerable population of the bereaved at high risk for CG. Early assessments, targeted interventions, and policy support tailored for the disaster-bereaved individuals are necessary to identify and alleviate symptoms of CG and to improve their well-being.展开更多
Zinc-air batteries(ZABs)offer tremendous potential in various industries and daily life due to their excellent energy density,safety and affordability.However,the practical application of ZABs has been severely hinder...Zinc-air batteries(ZABs)offer tremendous potential in various industries and daily life due to their excellent energy density,safety and affordability.However,the practical application of ZABs has been severely hindered by challenges such as high low round-trip efficiencies and overpotential,primarily attributed to the inherent sluggish kinetics in the oxygen evolution reaction(OER)of air electrocatalysts.To address these issues effectively and economically,heterojunction engineering accompanied by interfacial chemistry emerges as an ideal approach to designing efficient OER electrocatalysts.Herein,a novel heterogeneous interfacial chemical structure,namely NiCoP/NiFe LDH(layered double hydroxide),needle-like NiCoP and NiFe LDH nanosheets were assembled from cores and shells,respectively.Remarkably,the NiCoP/NiFe LDH-based ZABs have an exceptionally long cycle life of 238 h,far superior to Pt/C+Ir/C batteries(~97 h).Theoretical calculations and experimental results demonstrate that NiCoP/NiFe LDH possesses tunable interfacial chemistry,demonstrating significant electronic,coordination,geometric and synergistic effects.These enhancements dramatically improve the active site density,intrinsic activity and electrochemical durability of the catalyst.In summary,this work provides a solid foundation for the development of costeffective OER electrocatalysts for electrochemical energy devices.展开更多
Objective:Early-onset preeclampsia(EOPE)manifests as elevated blood pressure and indications of organ damage,predominantly in the kidneys,in women before 34 weeks of gestation.A growing body of evidence suggests that ...Objective:Early-onset preeclampsia(EOPE)manifests as elevated blood pressure and indications of organ damage,predominantly in the kidneys,in women before 34 weeks of gestation.A growing body of evidence suggests that hypoxia triggers a series of maladaptive responses culminating in the progression of EOPE.However,the precise mechanisms underlying these processes remain largely undefined.This study aimed to map the dynamic interplay within the competing endogenous RNA(ceRNA)network in EOPE under hypoxic conditions to provide insights into its molecular etiology.Methods:To investigate the oxidative stress response in EOPE,RNA sequencing data(ID:GSE119265)were retrieved from the Gene Expression Omnibus database for exhaustive analysis.Oxygen-sensitive differentially expressed genes(DEGs)were identified by comparing EOPE samples to controls at 5%and 20%O2 concentrations,respectively.Furthermore,the STRING database facilitated the construction of a protein–protein interaction network,highlighting critical hub genes among the identified DEGs.Results:An intricate ceRNA network encompassing four representative DEGs(AOC1,DCN,TGFB1,andSYNE3)and seven differentially expressed long non-coding RNAs(HCG27,MEG3,XIST,LINC01119,LINC00964,LINC01118,andLINC01588)was established.Conclusions:Our analysis revealed a set of long non-coding RNA that respond to hypoxic stress,shedding light on their possible roles in the oxygen-dependent pathophysiology of EOPE.These insights offer new avenues for targeted EOPE diagnosis and treatment.Further studies are required to elucidate their precise functions.展开更多
文摘Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of“Guidance for maternal and fctal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital".This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection diagnostic criteria,inspection precautions,drug treatment options,indications and methods of termination of pregnancy,postpartum fever,breastfeeding considerations,mode of mother-to-child transmission,neonatal isolation and advice on nconatal nursing,to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns.
基金This study was supported by Emergency Technology Research Project of Huazhong University of Science and Technology(No.2020kfyXGYJ020).
文摘Objective This study aimed to explore the clinical value of Children Neuropsychological and Behavioral Scale-Revision 2016(CNBS-R2016)for Autism Spectrum Disorder(ASD)screening in the presence of developmental surveillance.Methods All participants were evaluated by the CNBS-R2016 and Gesell Developmental Schedules(GDS).Spearman’s correlation coefficients and Kappa values were obtained.Taking GDS as a reference assessment,the performance of the CNBS-R2016 for detecting the developmental delays of children with ASD was analyzed with receiver operating characteristic(ROC)curves.The efficacy of the CNBS-R2016 to screen for ASD was explored by comparing Communication Warning Behavior with Autism Diagnostic Observation Schedule,Second Edition(ADOS-2).Results In total,150 children aged 12–42 months with ASD were enrolled.The developmental quotients of the CNBS-R2016 were correlated with those of the GDS(r=0.62–0.94).The CNBS-R2016 and GDS had good diagnostic agreement for developmental delays(Kappa=0.73–0.89),except for Fine Motor.There was a significant difference between the proportions of Fine Motor,delays detected by the CNBS-R2016 and GDS(86.0%vs.77.3%).With GDS as a standard,the areas under the ROC curves of the CNBS-R2016 were above 0.95 for all the domains except Fine Motor,which was 0.70.In addition,the positive rate of ASD was 100.0%and 93.5%when the cut-off points of 7 and 12 in the Communication Warning Behavior subscale were used,respectively.Conclusion The CNBS-R2016 performed well in developmental assessment and screening for children with ASD,especially by Communication Warning Behaviors subscale.Therefore,the CNBS-R2016 is worthy of clinical application in children with ASD in China.
文摘Background： The Wenchuan earthquake in China caused shock and grief worldwide. Sudden bereavement caused by the earthquake led to physical disorders as well as psychological disturbances in the bereaved individuals. The bereaved had a high risk for complicated grief （CG）, which may have led to significant distress and impairment in their health. However, there was few available studies on CG among disaster-bereaved individuals in China after the disaster. The aim of this study was to identify factors （demographic characteristics and disaster-related variables） associated with symptoms of CG among the bereaved 18 months after the Wenchuan earthquake. Methods： This study was conducted with a cross-sectional design and a convenience sample of 271 bereaved individuals from three of the hardest hit areas. Data were collected by questionnaires and the instruments used in the study were： General questionnaire and Inventory of CG （ICG）. Multivariate linear regression analysis was used to identify factors associated with symptoms of CG. Results： The mean score on ICG was 52.77 （standard deviation： 10.00）. Being female and loss of a child were related to higher level of CG while having another child after the disaster and receiving psychological counseling experience were associated with lower level of CG. Forty-nine percent of the variance of CG was explained by these identified factors. Conclusions： Eighteen months after the Wenchuan earthquake, the symptoms of CG among the bereaved were higher than the previous studies with bereaved individuals. This study uncovers a vulnerable population of the bereaved at high risk for CG. Early assessments, targeted interventions, and policy support tailored for the disaster-bereaved individuals are necessary to identify and alleviate symptoms of CG and to improve their well-being.
基金financially supported by the National Natural Science Foundation of China(Nos.22309023 and22179014)China Postdoctoral Science Foundation(No.2022M720593)+3 种基金the Scientific Research Foundation of Chongqing University of Technology(Nos.2022ZDZ011 and 2022PYZ026)the Youth Project of Science and Technology Research Program of Chongqing Municipal Education Commission of China(No.KJQN202201127)the Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-MSX0270)the Special Funding for Research Projects of Chongqing Human Resources and Social Security Bureau(No.2022CQBSHTB1023)。
文摘Zinc-air batteries(ZABs)offer tremendous potential in various industries and daily life due to their excellent energy density,safety and affordability.However,the practical application of ZABs has been severely hindered by challenges such as high low round-trip efficiencies and overpotential,primarily attributed to the inherent sluggish kinetics in the oxygen evolution reaction(OER)of air electrocatalysts.To address these issues effectively and economically,heterojunction engineering accompanied by interfacial chemistry emerges as an ideal approach to designing efficient OER electrocatalysts.Herein,a novel heterogeneous interfacial chemical structure,namely NiCoP/NiFe LDH(layered double hydroxide),needle-like NiCoP and NiFe LDH nanosheets were assembled from cores and shells,respectively.Remarkably,the NiCoP/NiFe LDH-based ZABs have an exceptionally long cycle life of 238 h,far superior to Pt/C+Ir/C batteries(~97 h).Theoretical calculations and experimental results demonstrate that NiCoP/NiFe LDH possesses tunable interfacial chemistry,demonstrating significant electronic,coordination,geometric and synergistic effects.These enhancements dramatically improve the active site density,intrinsic activity and electrochemical durability of the catalyst.In summary,this work provides a solid foundation for the development of costeffective OER electrocatalysts for electrochemical energy devices.
基金National Natural Science Foundation of China(No.82303948)。
文摘Objective:Early-onset preeclampsia(EOPE)manifests as elevated blood pressure and indications of organ damage,predominantly in the kidneys,in women before 34 weeks of gestation.A growing body of evidence suggests that hypoxia triggers a series of maladaptive responses culminating in the progression of EOPE.However,the precise mechanisms underlying these processes remain largely undefined.This study aimed to map the dynamic interplay within the competing endogenous RNA(ceRNA)network in EOPE under hypoxic conditions to provide insights into its molecular etiology.Methods:To investigate the oxidative stress response in EOPE,RNA sequencing data(ID:GSE119265)were retrieved from the Gene Expression Omnibus database for exhaustive analysis.Oxygen-sensitive differentially expressed genes(DEGs)were identified by comparing EOPE samples to controls at 5%and 20%O2 concentrations,respectively.Furthermore,the STRING database facilitated the construction of a protein–protein interaction network,highlighting critical hub genes among the identified DEGs.Results:An intricate ceRNA network encompassing four representative DEGs(AOC1,DCN,TGFB1,andSYNE3)and seven differentially expressed long non-coding RNAs(HCG27,MEG3,XIST,LINC01119,LINC00964,LINC01118,andLINC01588)was established.Conclusions:Our analysis revealed a set of long non-coding RNA that respond to hypoxic stress,shedding light on their possible roles in the oxygen-dependent pathophysiology of EOPE.These insights offer new avenues for targeted EOPE diagnosis and treatment.Further studies are required to elucidate their precise functions.
