Interleukins(ILs),a subset of cytokines,play a critical role in the pathogenesis of coronary heart disease(CHD)by mediating inflammation.This review article summarizes the role of ILs such as IL-1,IL-2,IL-3,IL-4,IL-5,...Interleukins(ILs),a subset of cytokines,play a critical role in the pathogenesis of coronary heart disease(CHD)by mediating inflammation.This review article summarizes the role of ILs such as IL-1,IL-2,IL-3,IL-4,IL-5,IL-6,IL-7,IL-8,IL-9,and IL-10 in the pathogenesis of CHD.Individuals with mild coronary artery disease(CAD)and angina who have ischemic heart disease have higher serum concentrations of IL-1b.Larger studies are needed to verify the safety and assess the effectiveness of low-dose IL-2 as an anti-inflammatory treatment.IL-3 is found more often in patients receiving coronary angioplasty compared to patients with asymptomatic CAD or without CAD.Serum levels of IL-4 are reliable indicators of CAD.An independent correlation between IL-5 and the incidence of CAD was demonstrated.IL-6 helps serve as a reliable biomarker for the degree of CAD,as determined by the Gensini score,and is a key factor in the development of atherosclerosis.Also,variants of IL-7/7R have been linked to the Han Chinese population's genetic susceptibility to CHD.IL-8 plays a role in the progression of CAD occurrences.By interacting with conventional risk factors for CAD,IL-9 may contribute to the development of CAD and offer an innovative approach to its prevention and management.There was a 34%increased risk of a CHD incident for every standard deviation rise in baseline IL-10 levels.展开更多
Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,bl...Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and phlegm.Failure can be caused by deficiency or disease.The pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each other.The theory of traditional Chinese medicine believes that the general rule is not painful.Therefore,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong tonic.The chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma Wentong.Based on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.展开更多
The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of...The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of coronary heart disease with blood biochemical indexes,such as blood lipid metabolism,inflammatory factors,coagulation-fibrinolysis system,blood rheology and vascular endothelial function,which was hoped to provide a guidance on the clinical combined application of TCM syndrome differentiation and biochemical indexes of coronary heart disease,so as to promote the objectification and standardization of TCM syndrome differentiation.展开更多
Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators ...Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators to conventional coronary heart disease(CHD)risk prediction.Methods Data of TCM indicators(tongue,facial,and pulse diagnostics)and clinical parame-ters from patients diagnosed with CHD at the Cardiology Department of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,from October 3,2023 to March 15,2024,were collected.Important variables were identified using importance screen-ing and correlation analysis with CHD risk factors and laboratory markers.Six machine learn-ing models including logistic regression(LR),decision tree(DT),support vector machine(SVM),k-nearest neighbors(KNN),random forest(RF),and gradient boosting(GB),were ap-plied to evaluate the risk of coronary artery obstruction by combining clinical and TCM data of CHD.Model performance was assessed using metrics such as accuracy,precision,and re-call,with reliability validated through ten-fold cross-validation.Results A total of 288 patients were included in the study.Fifteen clinical risk factors,includ-ing body mass index(BMI),myoglobin,and alcohol consumption history,were incorporated into the diagnostic models.The KNN model showed good performance when combining clin-ical data with tongue and facial data.The SVM model performed well when clinical data was combined with pulse data.Among all the models,the KNN model with 10-fold cross-valida-tion,which integrates the three types of TCM diagnostic data(tongue,face,and pulse)with clinical data,performs the best(accuracy:0.837,precision:0.814,and recall:0.809).Conclusion Incorporating TCM diagnostic data can enhance the accuracy of coronary artery obstruction risk assessment.The KNN prediction model that integrate tongue,facial,and pulse data performs the best and can be recommended as a clinical decision support tool.展开更多
文摘Interleukins(ILs),a subset of cytokines,play a critical role in the pathogenesis of coronary heart disease(CHD)by mediating inflammation.This review article summarizes the role of ILs such as IL-1,IL-2,IL-3,IL-4,IL-5,IL-6,IL-7,IL-8,IL-9,and IL-10 in the pathogenesis of CHD.Individuals with mild coronary artery disease(CAD)and angina who have ischemic heart disease have higher serum concentrations of IL-1b.Larger studies are needed to verify the safety and assess the effectiveness of low-dose IL-2 as an anti-inflammatory treatment.IL-3 is found more often in patients receiving coronary angioplasty compared to patients with asymptomatic CAD or without CAD.Serum levels of IL-4 are reliable indicators of CAD.An independent correlation between IL-5 and the incidence of CAD was demonstrated.IL-6 helps serve as a reliable biomarker for the degree of CAD,as determined by the Gensini score,and is a key factor in the development of atherosclerosis.Also,variants of IL-7/7R have been linked to the Han Chinese population's genetic susceptibility to CHD.IL-8 plays a role in the progression of CAD occurrences.By interacting with conventional risk factors for CAD,IL-9 may contribute to the development of CAD and offer an innovative approach to its prevention and management.There was a 34%increased risk of a CHD incident for every standard deviation rise in baseline IL-10 levels.
基金National natural science foundation of China(No.81774247)
文摘Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and phlegm.Failure can be caused by deficiency or disease.The pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each other.The theory of traditional Chinese medicine believes that the general rule is not painful.Therefore,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong tonic.The chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma Wentong.Based on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.
基金General Project of National Natural Science Foundation of China(No.81774260)。
文摘The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of coronary heart disease with blood biochemical indexes,such as blood lipid metabolism,inflammatory factors,coagulation-fibrinolysis system,blood rheology and vascular endothelial function,which was hoped to provide a guidance on the clinical combined application of TCM syndrome differentiation and biochemical indexes of coronary heart disease,so as to promote the objectification and standardization of TCM syndrome differentiation.
基金National Natural Science Foundation of China(82104738)High-Level Key Discipline Construction Project in Traditional Chinese Medicine Diagnostics by the National Administration of Traditional Chinese Medicine(ZYYZDXK-2023069)Clinical Research Project in the Health Industry by Shanghai Municipal Health Commission(20244Y0129).
文摘Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators to conventional coronary heart disease(CHD)risk prediction.Methods Data of TCM indicators(tongue,facial,and pulse diagnostics)and clinical parame-ters from patients diagnosed with CHD at the Cardiology Department of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,from October 3,2023 to March 15,2024,were collected.Important variables were identified using importance screen-ing and correlation analysis with CHD risk factors and laboratory markers.Six machine learn-ing models including logistic regression(LR),decision tree(DT),support vector machine(SVM),k-nearest neighbors(KNN),random forest(RF),and gradient boosting(GB),were ap-plied to evaluate the risk of coronary artery obstruction by combining clinical and TCM data of CHD.Model performance was assessed using metrics such as accuracy,precision,and re-call,with reliability validated through ten-fold cross-validation.Results A total of 288 patients were included in the study.Fifteen clinical risk factors,includ-ing body mass index(BMI),myoglobin,and alcohol consumption history,were incorporated into the diagnostic models.The KNN model showed good performance when combining clin-ical data with tongue and facial data.The SVM model performed well when clinical data was combined with pulse data.Among all the models,the KNN model with 10-fold cross-valida-tion,which integrates the three types of TCM diagnostic data(tongue,face,and pulse)with clinical data,performs the best(accuracy:0.837,precision:0.814,and recall:0.809).Conclusion Incorporating TCM diagnostic data can enhance the accuracy of coronary artery obstruction risk assessment.The KNN prediction model that integrate tongue,facial,and pulse data performs the best and can be recommended as a clinical decision support tool.
