Amino acid composition of Astragalus Membranaceus Bge(AMB)was analysed by automatic analyzer.The results showed that the amount of combined amino acids was 8.05%of total weight,the free amino acids was 0.38%and the wh...Amino acid composition of Astragalus Membranaceus Bge(AMB)was analysed by automatic analyzer.The results showed that the amount of combined amino acids was 8.05%of total weight,the free amino acids was 0.38%and the whole amino acids was 8.43%.AMB contains all of the essential amino acids except Trp xysshhant.Besides the therapy effect,the AMB has significant nutrient effect.展开更多
Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial effects.Polysaccharides,one kind of the majo...Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial effects.Polysaccharides,one kind of the major active ingredients of A.membranaceus,are considered to be responsible for their versatile use.Now,a systematic summary of research progress and prospects of polysaccharides from A.membranaceus polysaccharides(AMPs)is necessary to facilitate their further study and application.In this review,the optimal extraction methods,structural features,biological activities,and applications of AMPs were emphasized.The structure-activity relationships are also analyzed and elucidated.Solvent,ultrasonic,microwave,enzyme-assisted,ultra-high pressure,and combined methods have been used to extract AMPs.Among them,solvent extraction is the most commonly used method because it is simple and easy to operate,but the efficiency needs to be improved further.The ultra-high pressure method is the most efficient but has a low economic return.AMPs exhibited various bioactivities,including immunomodulation,antitumor,and antidiabete.The structure-activity relationships revealed that different structure configurations,chain conformations,and physical properties would have different bioactivities.However,the new method for purification of certain polysaccharides,detailed structure-activity relationships(SAR),mechanisms of bioactivities,and quality control of AMPs need to be extensively investigated.展开更多
[Objectives] The content of astragaloside in Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hisao from three different regions was determined.[Methods] Referring to the method recorded in the Chinese Pharma...[Objectives] The content of astragaloside in Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hisao from three different regions was determined.[Methods] Referring to the method recorded in the Chinese Pharmacopoeia(2015 edition),the content of astragaloside IV in A.membranaceus was determined by HPLC.[Results] There were great differences in the astragaloside IV content of A.membranaceus among different regions.The content of astragaloside IV in A.membranaceus cultivated in Inner Mongolia was highest(0.155%),followed by that(0.143%) in A.membranaceus cultivated in Gansu,and the content of astragaloside IV in A.membranaceus cultivated in Shanxi was lowest(0.080%).The contents of astragaloside IV in A.membranaceus from different regions were all in line with the standard(not less than 0.040%) of Chinese Pharmacopoeia(2015 edition).[Conclusions]The content of astragaloside IV in A.membranaceus cultivated in three different regions met the medicinal standards.展开更多
文摘Amino acid composition of Astragalus Membranaceus Bge(AMB)was analysed by automatic analyzer.The results showed that the amount of combined amino acids was 8.05%of total weight,the free amino acids was 0.38%and the whole amino acids was 8.43%.AMB contains all of the essential amino acids except Trp xysshhant.Besides the therapy effect,the AMB has significant nutrient effect.
基金supported by Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202005)Key project at central government level(No.2060302)+1 种基金National Natural Science Foundation of China(No.81872956)Special Project for Transformation of Scientific and Technological Achievements in Qinghai Province(No.2021-SF-150)。
文摘Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial effects.Polysaccharides,one kind of the major active ingredients of A.membranaceus,are considered to be responsible for their versatile use.Now,a systematic summary of research progress and prospects of polysaccharides from A.membranaceus polysaccharides(AMPs)is necessary to facilitate their further study and application.In this review,the optimal extraction methods,structural features,biological activities,and applications of AMPs were emphasized.The structure-activity relationships are also analyzed and elucidated.Solvent,ultrasonic,microwave,enzyme-assisted,ultra-high pressure,and combined methods have been used to extract AMPs.Among them,solvent extraction is the most commonly used method because it is simple and easy to operate,but the efficiency needs to be improved further.The ultra-high pressure method is the most efficient but has a low economic return.AMPs exhibited various bioactivities,including immunomodulation,antitumor,and antidiabete.The structure-activity relationships revealed that different structure configurations,chain conformations,and physical properties would have different bioactivities.However,the new method for purification of certain polysaccharides,detailed structure-activity relationships(SAR),mechanisms of bioactivities,and quality control of AMPs need to be extensively investigated.
基金Supported by Tianjin Natural Science Fund(17JCYBJC29800)Tianjin Agricultural College Various Talents Funding Plan Project(J01009030702)+1 种基金Science and Technology Project in the Field of Social Development of Binhai New Area,TianjinAgricultural Science and Technology Plan Project of Baodi District,Tianjin(201838)
文摘[Objectives] The content of astragaloside in Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hisao from three different regions was determined.[Methods] Referring to the method recorded in the Chinese Pharmacopoeia(2015 edition),the content of astragaloside IV in A.membranaceus was determined by HPLC.[Results] There were great differences in the astragaloside IV content of A.membranaceus among different regions.The content of astragaloside IV in A.membranaceus cultivated in Inner Mongolia was highest(0.155%),followed by that(0.143%) in A.membranaceus cultivated in Gansu,and the content of astragaloside IV in A.membranaceus cultivated in Shanxi was lowest(0.080%).The contents of astragaloside IV in A.membranaceus from different regions were all in line with the standard(not less than 0.040%) of Chinese Pharmacopoeia(2015 edition).[Conclusions]The content of astragaloside IV in A.membranaceus cultivated in three different regions met the medicinal standards.
