对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相...对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.展开更多
γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is respo...γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.展开更多
Based on the number of customers and the server’s workload,this paper proposes a modified Min(N,D)-policy and discusses an M/G/1 queueing model with delayed randomized multiple vacations under such a policy.Applying ...Based on the number of customers and the server’s workload,this paper proposes a modified Min(N,D)-policy and discusses an M/G/1 queueing model with delayed randomized multiple vacations under such a policy.Applying the well-known stochastic decomposition property of the steady-state queue size,the probability generating function of the steady-state queue length distribution is obtained.Moreover,the explicit expressions of the expected queue length and the additional queue length distribution are derived by some algebraic manipulations.Finally,employing the renewal reward theorem,the explicit expression of the long-run expected cost per unit time is given.Furthermore,we analyze the optimal policy for economizing the expected cost and compare the optimal Min(N,D)-policy with the optimal N-policy and the optimal D-policy by using numerical examples.展开更多
配电网状态监测系统建设是构建泛在电力物联网的重要内容,准确预测通信网络带宽对明确业务需求、优化资源配置具有重要意义。针对当前配用电基于排队论的通信带宽预测方法在混合业务并存时带宽计算过程复杂的局限性,提出了一种基于G/M/...配电网状态监测系统建设是构建泛在电力物联网的重要内容,准确预测通信网络带宽对明确业务需求、优化资源配置具有重要意义。针对当前配用电基于排队论的通信带宽预测方法在混合业务并存时带宽计算过程复杂的局限性,提出了一种基于G/M/1/N队列模型的通信带宽预测方法。从状态监测系统架构和数据业务特点出发,分析混合数据业务到达时间间隔的统计描述以及基本传输速率,并给出了满足服务质量(quality of service,QoS)要求的系统带宽最优化化求解方法。以典型配电网状态监测应用为例,讨论了业务带宽、服务质量和带宽利用率之间的量化评价过程;验证了配电网状态监测网络信息流的"小数据"特征,为低功耗广域物联网通信技术在配电网状态监测中的应用提供了理论支撑。展开更多
文摘对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.
基金the programs for the postdoctoral fellowships-Chilean CONICYT-FONDECYT#3140218,Mexican CONACYT#164978 and DID-UACh S-2015-81Sistema Nacional de Investigadores#58512 to Abraham Rosas-Arellano+2 种基金supported by USACH PhD fellowshipsupported with a PhD fellowship from CONACYT(#299627)FONDECYT grants 1151206 and 1110571 to Maite A.Castro
文摘γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.
基金supported by the National Natural Science Foundation of China(No.71571127)the National Natural Science Youth Foundation of China(No.72001181).
文摘Based on the number of customers and the server’s workload,this paper proposes a modified Min(N,D)-policy and discusses an M/G/1 queueing model with delayed randomized multiple vacations under such a policy.Applying the well-known stochastic decomposition property of the steady-state queue size,the probability generating function of the steady-state queue length distribution is obtained.Moreover,the explicit expressions of the expected queue length and the additional queue length distribution are derived by some algebraic manipulations.Finally,employing the renewal reward theorem,the explicit expression of the long-run expected cost per unit time is given.Furthermore,we analyze the optimal policy for economizing the expected cost and compare the optimal Min(N,D)-policy with the optimal N-policy and the optimal D-policy by using numerical examples.
文摘配电网状态监测系统建设是构建泛在电力物联网的重要内容,准确预测通信网络带宽对明确业务需求、优化资源配置具有重要意义。针对当前配用电基于排队论的通信带宽预测方法在混合业务并存时带宽计算过程复杂的局限性,提出了一种基于G/M/1/N队列模型的通信带宽预测方法。从状态监测系统架构和数据业务特点出发,分析混合数据业务到达时间间隔的统计描述以及基本传输速率,并给出了满足服务质量(quality of service,QoS)要求的系统带宽最优化化求解方法。以典型配电网状态监测应用为例,讨论了业务带宽、服务质量和带宽利用率之间的量化评价过程;验证了配电网状态监测网络信息流的"小数据"特征,为低功耗广域物联网通信技术在配电网状态监测中的应用提供了理论支撑。
